Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the TracerLab FXFN and TracerLab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

Bourdier, T; Pham, TQ; Henderson, D; Jackson, TW; Lam, P; Izard, M; Katsifis, A

Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the TracerLab FXFN and TracerLab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

Date

2012-01-01

Authors

Publisher

Pergamon-Elsevier Science Ltd

Abstract

[F-18]PBR111 and [F-18]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [F-18]PBR111 and [F-18]PBR102 in the Tracerlab FXFN (30 +/- 2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25 +/- 2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was > 99% and specific activity was > 150 GBq/mu mol after less than 60 min of preparation time. © 2012, Elsevier Ltd.

Keywords

Positron computed tomography, Receptors, Ligands, Impurities, In vivo, Brain

Citation

Bourdier, T., Pham, T.Q., Henderson, D., Jackson, T., Lam, P., Izard, M., & Katsifis, A. (2012). Automated radiosynthesis of f-18 pbr111 and f-18 pbr102 using the tracerlab fxfn and tracerlab mxfdg module for imaging the peripheral benzodiazepine receptor with pet. Applied Radiation and Isotopes, 70(1), 176-183. doi:10.1016/j.apradiso.2011.07.014