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|Title: ||Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the TracerLab FXFN and TracerLab MXFDG module for imaging the peripheral benzodiazepine receptor with PET|
|Authors: ||Bourdier, T|
Pham, T Q
|Keywords: ||POSITRON COMPUTED TOMOGRAPHY|
|Issue Date: ||1-Jan-2012|
|Publisher: ||Pergamon-Elsevier Science Ltd|
|Citation: ||Bourdier, T., Pham, T.Q., Henderson, D., Jackson, T., Lam, P., Izard, M., & Katsifis, A. (2012). Automated radiosynthesis of f-18 pbr111 and f-18 pbr102 using the tracerlab fxfn and tracerlab mxfdg module for imaging the peripheral benzodiazepine receptor with pet. Applied Radiation and Isotopes, 70(1), 176-183.|
|Abstract: ||[F-18]PBR111 and [F-18]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [F-18]PBR111 and [F-18]PBR102 in the Tracerlab FXFN (30 +/- 2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25 +/- 2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was > 99% and specific activity was > 150 GBq/mu mol after less than 60 min of preparation time. © 2012, Elsevier Ltd.|
|Appears in Collections:||Journal Articles|
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