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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/6120

Title: Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the TracerLab FXFN and TracerLab MXFDG module for imaging the peripheral benzodiazepine receptor with PET
Authors: Bourdier, T
Pham, T Q
Henderson, D
Jackson, T
Lam, P
Izard, M
Katsifis, A
Keywords: POSITRON COMPUTED TOMOGRAPHY
RECEPTORS
FLUORINATION
IMPURITIES
IN VIVO
BRAIN
Issue Date: 1-Jan-2012
Publisher: Pergamon-Elsevier Science Ltd
Citation: Bourdier, T., Pham, T.Q., Henderson, D., Jackson, T., Lam, P., Izard, M., & Katsifis, A. (2012). Automated radiosynthesis of f-18 pbr111 and f-18 pbr102 using the tracerlab fxfn and tracerlab mxfdg module for imaging the peripheral benzodiazepine receptor with pet. Applied Radiation and Isotopes, 70(1), 176-183.
Abstract: [F-18]PBR111 and [F-18]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [F-18]PBR111 and [F-18]PBR102 in the Tracerlab FXFN (30 +/- 2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25 +/- 2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was > 99% and specific activity was > 150 GBq/mu mol after less than 60 min of preparation time. © 2012, Elsevier Ltd.
URI: http://dx.doi.org/10.1016/j.apradiso.2011.07.014
http://apo.ansto.gov.au/dspace/handle/10238/6120
ISSN: 0969-8043
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