Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the TracerLab FXFN and TracerLab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

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dc.contributor.authorBourdier, Ten_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorHenderson, Den_AU
dc.contributor.authorJackson, TWen_AU
dc.contributor.authorLam, Pen_AU
dc.contributor.authorIzard, Men_AU
dc.contributor.authorKatsifis, Aen_AU
dc.date.accessioned2015-01-28T03:30:47Zen_AU
dc.date.available2015-01-28T03:30:47Zen_AU
dc.date.issued2012-01-01en_AU
dc.date.statistics2015-01-28en_AU
dc.description.abstract[F-18]PBR111 and [F-18]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [F-18]PBR111 and [F-18]PBR102 in the Tracerlab FXFN (30 +/- 2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25 +/- 2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was > 99% and specific activity was > 150 GBq/mu mol after less than 60 min of preparation time. © 2012, Elsevier Ltd.en_AU
dc.identifier.citationBourdier, T., Pham, T.Q., Henderson, D., Jackson, T., Lam, P., Izard, M., & Katsifis, A. (2012). Automated radiosynthesis of f-18 pbr111 and f-18 pbr102 using the tracerlab fxfn and tracerlab mxfdg module for imaging the peripheral benzodiazepine receptor with pet. Applied Radiation and Isotopes, 70(1), 176-183. doi:10.1016/j.apradiso.2011.07.014en_AU
dc.identifier.govdoc5699en_AU
dc.identifier.issn0969-8043en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleApplied Radiation and Isotopesen_AU
dc.identifier.pagination176-183en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.apradiso.2011.07.014en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6120en_AU
dc.identifier.volume70en_AU
dc.language.isoenen_AU
dc.publisherPergamon-Elsevier Science Ltden_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectReceptorsen_AU
dc.subjectLigandsen_AU
dc.subjectImpuritiesen_AU
dc.subjectIn vivoen_AU
dc.subjectBrainen_AU
dc.titleAutomated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the TracerLab FXFN and TracerLab MXFDG module for imaging the peripheral benzodiazepine receptor with PETen_AU
dc.typeJournal Articleen_AU
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