Development of activity standard for 90Y microspheres

Mo, L; Avci, B; James, D; Simpson, BRS; van Wyngaardt, WM; Cessna, JT; Baldock, C

Development of activity standard for 90Y microspheres

Date

2005-08

Authors

Publisher

Elsevier

Abstract

90Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of 90Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for 90Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of 90Y microsphere concentration. © 2005, Elsevier Ltd.

Keywords

Yttrium 90, Microspheres, Activity levels, Digestion, Ionization chambers, Calibration

Citation

Mo, L., Avci, B., James, D., Simpson, B., van Wyngaardt, W. M., Cessna, J. T., & Baldock, C. (2005). Development of activity standard for 90Y microspheres. Applied Radiation and Isotopes, 63(2), 193-199. doi:10.1016/j.apradiso.2005.02.002