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Title: Development of activity standard for 90Y microspheres.
Authors: Mo, L
Avci, B
James, D
Simpson, B
van Wyngaardt, WM
Cessna, JT
Baldock, C
Keywords: Yttrium 90
Activity Levels
Ionization Chambers
Issue Date: Aug-2005
Publisher: Elsevier
Citation: Mo, L., Avci, B., James, D., Simpson, B., van Wyngaardt, W. M., Cessna, J. T., et al. (2005). Development of activity standard for 90Y microspheres. Applied Radiation and Isotopes, 63(2), 193-199.
Abstract: 90Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of 90Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for 90Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of 90Y microsphere concentration. © 2005, Elsevier Ltd.
ISSN: 0969-8043
Appears in Collections:Journal Articles

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