Development of activity standard for 90Y microspheres

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dc.contributor.authorMo, Len_AU
dc.contributor.authorAvci, Ben_AU
dc.contributor.authorJames, Den_AU
dc.contributor.authorSimpson, BRSen_AU
dc.contributor.authorvan Wyngaardt, WMen_AU
dc.contributor.authorCessna, JTen_AU
dc.contributor.authorBaldock, Cen_AU
dc.date.accessioned2010-08-24T02:00:46Zen_AU
dc.date.available2010-08-24T02:00:46Zen_AU
dc.date.issued2005-08en_AU
dc.date.statistics2005-08en_AU
dc.description.abstract90Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres® is a radiopharmaceutical product that is comprised of 90Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres® production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres® was developed from a standard for 90Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres® product placed in Wheaton vials, for both 34% and 44% of 90Y microsphere concentration. © 2005, Elsevier Ltd.en_AU
dc.identifier.citationMo, L., Avci, B., James, D., Simpson, B., van Wyngaardt, W. M., Cessna, J. T., & Baldock, C. (2005). Development of activity standard for 90Y microspheres. Applied Radiation and Isotopes, 63(2), 193-199. doi:10.1016/j.apradiso.2005.02.002en_AU
dc.identifier.govdoc2528en_AU
dc.identifier.issn0969-8043en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleApplied Radiation and Isotopesen_AU
dc.identifier.pagination193-199en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.apradiso.2005.02.002en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/2328en_AU
dc.identifier.volume63en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectYttrium 90en_AU
dc.subjectMicrospheresen_AU
dc.subjectActivity levelsen_AU
dc.subjectDigestionen_AU
dc.subjectIonization chambersen_AU
dc.subjectCalibrationen_AU
dc.titleDevelopment of activity standard for 90Y microspheresen_AU
dc.typeJournal Articleen_AU
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