First extensive study of lanthanum manganite nanoparticles to target deadly brain cancer
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Date
2020-11-11
Journal Title
Journal ISSN
Volume Title
Publisher
Australian Institute of Nuclear Science and Engineering (AINSE)
Abstract
The ability to successfully target deep-seated tumours in sensitive areas of the body is limited to adequate targeting strategies. More specifically, brain and central nervous system (CNS) cancers can be the most aggressive, have higher mortality rates and lower accessibility to chemotherapeutic drugs. A proposed solution to target these concerns is through introducing high atomic number (Z) nanoparticles (NPs) such as silver-doped lanthanum manganite (LAGMO) to aid in common treatments such as radiation therapy.
These NPs can bypass the blood brain barrier and are capable of increasing the damage from the radiation due to their high-Z. Most importantly they have potential to cause cancer cells to undergo hyperthermia (a cell death precursor) as the NPs heat up in their environment due to their Curie temperature being in the
hyperthermia range of interest.
Description
Keywords
Central nervous system, Brain, Targets, Neoplasms, Chemotherapy, Nanoparticles, Hyperthermia, Damage
Citation
Khochaiche, A., Westlake, M., O'Keefe, A., Engels, E., Li, N., Vogel, S., Valceski, M., Konstantinov, K., Corde, S., Lerch, M., Tehei, M., Rule, K., & Horvat, J. (2020). First extensive study of lanthanum manganite nanoparticles to target deadly brain cancer. Paper presented to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2020, Virtual Meeting, 11th - 13th November 2020, (pp. 24). Retrieved from: https://events01.synchrotron.org.au/event/125/attachments/725/1149/AANSS_Abstract_Booklet_Complete_-_1_Page_Reduced.pdf