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    The distribution of the total energy of the fission system at the scission point
    (Australian Institute of Nuclear Science and Engineering, 1970-02-16) Ajitanand, NN; Boldeman, JW; Walsh. RL
    Not available see scanned image.
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    Modeling an epithermal neutron beam for a DIDO type reactor using MCNP - a Monte Carlo code
    (Plenum Press, 1992) Ross, D; Constantine, G; Weaver, DR
    Epithermal neutron beams are currently being developed for use in BNCT. They have the advantage over thermal beams in that they can achieve better penetration and can therefore treat deeper tumors. It has been shown that the optimum energy range for epithermal neutrons is approximately from 0.5 eV to 10 keV; energies above this range give significant damage due to proton recoil. The original aim of this project was to design an epithermal neutron beam for Harwell's DIDO reactor 10H beam tube, but the reactor was closed down in March, 1990. DIDO was a 25MW(th) research reactor, cooled and moderated by D2O. To model the reactor the Monte Carlo code MCNP was used. Initially, calculations were made to model an experimental setup that was used in 1987 to carry out cell irradiations with an Al/S/Ar filtered beam. Using this experience a study was begun to design an optimum epithermal beam for the 10H beam tube, a 10 inch diameter horizontal tube which penetrates the shield and radial reflector to within 9 cm of the core. © Plemum Press.
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    In vitro incorporation of boronophenylalanine by amelanotic and melanotic murine and human malignant melanoma cell lines
    (Plenum Press, 1992) Brown, JK; Allen, BJ; Champan, JE; Mountford, MH; Parsons, P
    Pelleted cells were irradiated as previously described, following a 20 h incubation in RPM1 1640 medium, in the presence or absence of 10μg/ml D,L-paraboronophenylalanine hydrochloride (10B1-BPA.HCl). Thermal neutrons were derived from Moata, a 100-kW Argonaut-type light water reactor. The neutron flux was 2.6 x 109 n/cm2/s, dose rate 3.7 Gy/h (n+γ) and the dose range 0.6 - 0.8 Gy. Cells were plated onto X-irradiated feeder layers in triplicate in 25cm2 Falcon flasks and colonies counted after 11-12 days. No differences in thermal neutron radiosensitivity were observed for two amelanotic cell lines. A small but significant difference was observed for the melanotic cell line (418) grown in the presence or absence of BPA. Subsequent experiments showed that the uptake of boron was low in the B16 murine malignant melanoma cell line cultured in the presence of BPA. It was therefore necessary to investigate the boron uptake and incorporation in melanoma cells by increasing the BPA concentration, increasing melanization using different variants of the B16 cell lines, and alternative methods of cell layer detachment. © Plenum Press
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    Uptake of boronated monoclonal antibodies by melanoma cells visualised by track etch autoradiography and electron energy loss spectroscopy.
    (Plenum Press, 1992) Moore, DE; Stretch, JR; Dawes, AL; Cockayne, DJH; Allen, BJ; Constantine, G
    The monoclonal antibody (MAb) NKI-C3 (Netherlands Cancer Institute) is a murine IgGl known to react with a formalin resistant antigen expressed by more than 95% of human melanomas. In principle, it can be used in the diagnosis of tissue sections for the presence of melanocytes, and with the appropriate level of boron labelling, this antibody could also be used for NCT of melanoma, provided its specificity is not impaired by the labelling process. The present study involves the use of two imaging techniques: first, α-track etch autoradiography to determine the specifiCity of the MAb after boronation, and second, electron energy loss spectroscopy to obtain information at the subcellular level concerning the localisation of the boron label. © Plenum Press
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    Liposomes as carriers of boronated thiouracils for NCT of melanoma
    (Plenum Press, 1992) Moore, DE; Chandler, AK; Corderoy-Buck, S; Wilson, JG; Allen, BJ
    5-(3-(1,2-decaboronyl)propyl)-6-methyl-thiouracil, DBTU-1, and 5-(1,2-decaboronyl-methyl)-6-methyl-thiouracil, DBTU-2, are boron derivative of thiouracil, which is reported to localize in melanoma as a false precursor in the synthesis of melanin. Biodistribution studies with nude mice bearing melanoma xenografts of both murine and human origin revealed only a slow uptake of boron by the various tumors 48-72 hours after intra peritoneal injection of DBTU-1 dissolved in a small volume of dimethyl-sulfoxide. The relatively slow absorption has been related to the very low aqueous solubility of these compounds. The solubility problem can be overcome by either modifying chemically the molecule, or by the design of an alternative drug delivery system to enhance the solubility. In this report, liposomes are examined as an example of the second approach. © Plenum Press