First extensive study of lanthanum manganite nanoparticles to target deadly brain cancer

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dc.contributor.authorKhochaiche, Aen_AU
dc.contributor.authorWestlake, Men_AU
dc.contributor.authorO'Keefe, Aen_AU
dc.contributor.authorEngels, Een_AU
dc.contributor.authorLi, Nen_AU
dc.contributor.authorVogel, Sen_AU
dc.contributor.authorValceski, Men_AU
dc.contributor.authorKonstantinov, Ken_AU
dc.contributor.authorCorde, Sen_AU
dc.contributor.authorLerch, MLFen_AU
dc.contributor.authorTehei, Men_AU
dc.contributor.authorRule, KCen_AU
dc.contributor.authorHorvat, Jen_AU
dc.date.accessioned2023-05-05T02:59:27Zen_AU
dc.date.available2023-05-05T02:59:27Zen_AU
dc.date.issued2020-11-11en_AU
dc.date.statistics2023-04-20en_AU
dc.description.abstractThe ability to successfully target deep-seated tumours in sensitive areas of the body is limited to adequate targeting strategies. More specifically, brain and central nervous system (CNS) cancers can be the most aggressive, have higher mortality rates and lower accessibility to chemotherapeutic drugs. A proposed solution to target these concerns is through introducing high atomic number (Z) nanoparticles (NPs) such as silver-doped lanthanum manganite (LAGMO) to aid in common treatments such as radiation therapy. These NPs can bypass the blood brain barrier and are capable of increasing the damage from the radiation due to their high-Z. Most importantly they have potential to cause cancer cells to undergo hyperthermia (a cell death precursor) as the NPs heat up in their environment due to their Curie temperature being in the hyperthermia range of interest.en_AU
dc.identifier.citationKhochaiche, A., Westlake, M., O'Keefe, A., Engels, E., Li, N., Vogel, S., Valceski, M., Konstantinov, K., Corde, S., Lerch, M., Tehei, M., Rule, K., & Horvat, J. (2020). First extensive study of lanthanum manganite nanoparticles to target deadly brain cancer. Paper presented to the ANBUG-AINSE Neutron Scattering Symposium, AANSS 2020, Virtual Meeting, 11th - 13th November 2020, (pp. 24). Retrieved from: https://events01.synchrotron.org.au/event/125/attachments/725/1149/AANSS_Abstract_Booklet_Complete_-_1_Page_Reduced.pdfen_AU
dc.identifier.conferenceenddate13 November 2020en_AU
dc.identifier.conferencenameANBUG-AINSE Neutron Scattering Symposium, AANSS 2020en_AU
dc.identifier.conferenceplaceVirtual Meetingen_AU
dc.identifier.conferencestartdate11 November 2020en_AU
dc.identifier.pagination24en_AU
dc.identifier.urihttps://events01.synchrotron.org.au/event/125/attachments/725/1149/AANSS_Abstract_Booklet_Complete_-_1_Page_Reduced.pdfen_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/15016en_AU
dc.language.isoenen_AU
dc.publisherAustralian Institute of Nuclear Science and Engineering (AINSE)en_AU
dc.subjectCentral nervous systemen_AU
dc.subjectBrainen_AU
dc.subjectTargetsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectChemotherapyen_AU
dc.subjectNanoparticlesen_AU
dc.subjectHyperthermiaen_AU
dc.subjectDamageen_AU
dc.titleFirst extensive study of lanthanum manganite nanoparticles to target deadly brain canceren_AU
dc.typeConference Abstracten_AU
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