Liposomes as carriers of boronated thiouracils for NCT of melanoma
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Date
1992
Journal Title
Journal ISSN
Volume Title
Publisher
Plenum Press
Abstract
5-(3-(1,2-decaboronyl)propyl)-6-methyl-thiouracil, DBTU-1, and 5-(1,2-decaboronyl-methyl)-6-methyl-thiouracil, DBTU-2, are boron derivative of thiouracil, which is reported to localize in melanoma as a false precursor in the synthesis of melanin. Biodistribution studies with nude mice bearing melanoma xenografts of both murine and human origin revealed only a slow uptake of boron by the various tumors 48-72 hours after intra peritoneal injection of DBTU-1 dissolved in a small volume of dimethyl-sulfoxide. The relatively slow absorption has been related to the very low aqueous solubility of these compounds. The solubility problem can be overcome by either modifying chemically the molecule, or by the design of an alternative drug delivery system to enhance the solubility. In this report, liposomes are examined as an example of the second approach. © Plenum Press
Description
Physical copy held at DDC: 616.994/17
Keywords
Biological localization, Boron 10, Boron compounds, Experimental neoplasms, Liposomes, Melanomas, Mice, Neutron capture therapy, Solubility, Thiouracil, Uptake
Citation
Moore, D. E., Chandler, A. K., Corderoy-Buck, S., Wilson, J. G., & Allen, B. J. (1992). Liposomes as carriers of boronated thiouracils for NCT of melanoma. Paper presented to the Fourth International Symposium on Neutron Capture Therapy for Cancer, December 4-7, 1990, Sydney, Australia. In B. J. Allen, D. E. Moore, & B. V. Harrington (Eds.), Progress in Neutron Capture Therapy for Cancer (pp. 451-454). New York, USA: Plenum Press.