Liposomes as carriers of boronated thiouracils for NCT of melanoma

Simple item page
dc.contributor.authorMoore, DEen_AU
dc.contributor.authorChandler, AKen_AU
dc.contributor.authorCorderoy-Buck, Sen_AU
dc.contributor.authorWilson, JGen_AU
dc.contributor.authorAllen, BJen_AU
dc.date.accessioned2026-01-02T06:24:26Zen_AU
dc.date.available2026-01-02T06:24:26Zen_AU
dc.date.issued1992en_AU
dc.date.statistics2025-11-24en_AU
dc.descriptionPhysical copy held at DDC: 616.994/17en_AU
dc.description.abstract5-(3-(1,2-decaboronyl)propyl)-6-methyl-thiouracil, DBTU-1, and 5-(1,2-decaboronyl-methyl)-6-methyl-thiouracil, DBTU-2, are boron derivative of thiouracil, which is reported to localize in melanoma as a false precursor in the synthesis of melanin. Biodistribution studies with nude mice bearing melanoma xenografts of both murine and human origin revealed only a slow uptake of boron by the various tumors 48-72 hours after intra peritoneal injection of DBTU-1 dissolved in a small volume of dimethyl-sulfoxide. The relatively slow absorption has been related to the very low aqueous solubility of these compounds. The solubility problem can be overcome by either modifying chemically the molecule, or by the design of an alternative drug delivery system to enhance the solubility. In this report, liposomes are examined as an example of the second approach. © Plenum Pressen_AU
dc.identifier.booktitleProgress in Neutron Capture Therapy for Canceren_AU
dc.identifier.citationMoore, D. E., Chandler, A. K., Corderoy-Buck, S., Wilson, J. G., & Allen, B. J. (1992). Liposomes as carriers of boronated thiouracils for NCT of melanoma. Paper presented to the Fourth International Symposium on Neutron Capture Therapy for Cancer, December 4-7, 1990, Sydney, Australia. In B. J. Allen, D. E. Moore, & B. V. Harrington (Eds.), Progress in Neutron Capture Therapy for Cancer (pp. 451-454). New York, USA: Plenum Press.en_AU
dc.identifier.conferenceenddate1990-12-07en_AU
dc.identifier.conferencenameFourth International Symposium on Neutron Capture Therapy for Canceren_AU
dc.identifier.conferenceplaceSydney, Australiaen_AU
dc.identifier.conferencestartdate1990-12-04en_AU
dc.identifier.editorsB. J. Allen, D. E. Moore, & B. V. Harringtonen_AU
dc.identifier.ismn0306441047en_AU
dc.identifier.pagination451-454en_AU
dc.identifier.placeofpublicationNew York, USAen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16820en_AU
dc.language.isoenen_AU
dc.publisherPlenum Pressen_AU
dc.subjectBiological localizationen_AU
dc.subjectBoron 10en_AU
dc.subjectBoron compoundsen_AU
dc.subjectExperimental neoplasmsen_AU
dc.subjectLiposomesen_AU
dc.subjectMelanomasen_AU
dc.subjectMiceen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectSolubilityen_AU
dc.subjectThiouracilen_AU
dc.subjectUptakeen_AU
dc.titleLiposomes as carriers of boronated thiouracils for NCT of melanomaen_AU
dc.typeConference Paperen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Conference Publications