Carrier-free 166Ho from 166Dy/166Ho biomedical generator system
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Date
1983-10-25
Journal Title
Journal ISSN
Volume Title
Publisher
Kyoto University
Abstract
Holmium-166 (166 Ho) is a potential candidate for various therapeutic applications (1-2) due
to its attractive properties which include emission of high-energy β− particles (Eav=666
MeV), an appropriate half-life (t1/2=26.4 h) and decay to stable daughter. ln addition, 166Ho
has chemical characteristics suitable for protein labelling through bifunctional chelates.
Holmium-166 also emits a low intensity and low energy γ-rays (80 keV, 6%) suitable for
imaging. Due to the absence of high energy γ-rays in its decay, 166Ho may be used for
outpatient therapy without significant external radiation to other individuals.
Although 166Ho, with a moderate specific activity, can be produced by a simple neutron
capture reaction, interestingly, its radionuclidic parent (81 .5-h 166Dy) can serve as a source
of high specific activity 166Ho. ln certain applications, such as protein labelling, the use
of a high specific activity radioisotope is essential. In addition, generator produced 166Ho
is free from 1200-γ 166mHo. This isotope is unavoidably coproduced with 166Ho by the
165Ho[n,γ] reaction (3).
Description
Physical copy held by ANSTO Library at DDC: 616.07575/115.
Keywords
Holmium 166, Dysprosium 166, Therapeutic doses, Radiopharmaceuticals, Stable isotopes, Neutron capture therapy, ANSTO, HIFAR Reactor, Irradiation, Nuclei, Chromatography, Cations
Citation
Mirzadeh, S., Hetherington, E., Knapp, F. F., & Lambrecht, R. M. (1983). Carrier-free 166Ho from 166Dy/166Ho biomedical generator system. Paper presented to the Tenth International Symposium on Radiopharmaceutical Chemistry, Kyoto University (October 25-28, 1983), (pp. 273-275). Kyoto, Japan : Kyoto University.