Carrier-free 166Ho from 166Dy/166Ho biomedical generator system

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dc.contributor.authorMirzadeh, Sen_AU
dc.contributor.authorHetherington, Een_AU
dc.contributor.authorKnapp, FFen_AU
dc.contributor.authorLambrecht, RMen_AU
dc.date.accessioned2025-10-30T00:44:12Zen_AU
dc.date.available2025-10-30T00:44:12Zen_AU
dc.date.issued1983-10-25en_AU
dc.date.statistics2025-08-08en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 616.07575/115.en_AU
dc.description.abstractHolmium-166 (166 Ho) is a potential candidate for various therapeutic applications (1-2) due to its attractive properties which include emission of high-energy β− particles (Eav=666 MeV), an appropriate half-life (t1/2=26.4 h) and decay to stable daughter. ln addition, 166Ho has chemical characteristics suitable for protein labelling through bifunctional chelates. Holmium-166 also emits a low intensity and low energy γ-rays (80 keV, 6%) suitable for imaging. Due to the absence of high energy γ-rays in its decay, 166Ho may be used for outpatient therapy without significant external radiation to other individuals. Although 166Ho, with a moderate specific activity, can be produced by a simple neutron capture reaction, interestingly, its radionuclidic parent (81 .5-h 166Dy) can serve as a source of high specific activity 166Ho. ln certain applications, such as protein labelling, the use of a high specific activity radioisotope is essential. In addition, generator produced 166Ho is free from 1200-γ 166mHo. This isotope is unavoidably coproduced with 166Ho by the 165Ho[n,γ] reaction (3).en_AU
dc.identifier.booktitleTenth International Symposium on Radiopharmaceutical Chemistry :abstracts under the auspice of Kyoto University (October 25-28, 1983)en_AU
dc.identifier.citationMirzadeh, S., Hetherington, E., Knapp, F. F., & Lambrecht, R. M. (1983). Carrier-free 166Ho from 166Dy/166Ho biomedical generator system. Paper presented to the Tenth International Symposium on Radiopharmaceutical Chemistry, Kyoto University (October 25-28, 1983), (pp. 273-275). Kyoto, Japan : Kyoto University.en_AU
dc.identifier.conferenceenddate1983-10-28en_AU
dc.identifier.conferencenameTenth International Symposium on Radiopharmaceutical Chemistryen_AU
dc.identifier.conferenceplaceKyoto, Japanen_AU
dc.identifier.conferencestartdate1983-10-25en_AU
dc.identifier.editorsInternational Symposium on Radiopharmaceutical Chemistryen_AU
dc.identifier.pagination273-275en_AU
dc.identifier.placeofpublicationKyoto, Japanen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16679en_AU
dc.language.isoenen_AU
dc.publisherKyoto Universityen_AU
dc.subjectHolmium 166en_AU
dc.subjectDysprosium 166en_AU
dc.subjectTherapeutic dosesen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectStable isotopesen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectANSTOen_AU
dc.subjectHIFAR Reactoren_AU
dc.subjectIrradiationen_AU
dc.subjectNucleien_AU
dc.subjectChromatographyen_AU
dc.subjectCationsen_AU
dc.titleCarrier-free 166Ho from 166Dy/166Ho biomedical generator systemen_AU
dc.typeConference Abstracten_AU
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