Drug elution form porous ceramic components for threshold reduction in pacemaker applications
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Date
1989-08
Journal Title
Journal ISSN
Volume Title
Publisher
Trans Tech Publications
Abstract
The implantation of heart pacemakers results in an inflammatory response in cardiac tissue which makes the electrode/tissue interface less favourable for energy transfer to the cardiac muscle, and increases the threshold voltage required to pace the heart. Minute porous alumina ceramic components with a tightly controlled bimodal pore size distribution have been developed to deliver a tiny amount of anti-inflammatory steroid right near the electrode/tissue interface. The pore structure, consisting of a 30% volume fraction of 7μm pores and a 30% volume fraction of 50-7Oμm pores is impregnated with dexamethasone sodium phosphate, which elutes slowly into the tissue near the interface. This device has been shown to be highly effective in reducing the threshold voltage in sheep.
Description
Physical copy of the journal held by ANSTO Library at DDC: 666/47
Conference name also called "2nd International Ceramic Conference and Exhibition" on preface.
Keywords
Drug delivery, Porosity, Ceramics, Cardiac Pacemakers, Inflammation, Steroids, Sheep, Heart
Citation
Anderson, N., Mathivanar, R., Skalsky, M., Drabarek, E., Buykx, W. J., & Reeve, K. D. (1989). Drug elution form porous ceramic components for threshold reduction in pacemaker applications. Presentation to the International Ceramic Conference (AUSTCERAM 90: ceramics technology - sharing the knowledge), Perth, Western Australia, 26-31 August 1990. In Journal of the Australian Ceramic Society, 25(2), 77.