Drug elution form porous ceramic components for threshold reduction in pacemaker applications

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dc.contributor.authorAnderson, Nen_AU
dc.contributor.authorMathivanar, Ren_AU
dc.contributor.authorSkalsky, Men_AU
dc.contributor.authorDrabarek, Een_AU
dc.contributor.authorBuykx, WJen_AU
dc.contributor.authorReeve, KDen_AU
dc.date.accessioned2025-09-01T06:51:21Zen_AU
dc.date.available2025-09-01T06:51:21Zen_AU
dc.date.issued1989-08en_AU
dc.date.statistics2025-08-01en_AU
dc.descriptionPhysical copy of the journal held by ANSTO Library at DDC: 666/47 Conference name also called "2nd International Ceramic Conference and Exhibition" on preface.en_AU
dc.description.abstractThe implantation of heart pacemakers results in an inflammatory response in cardiac tissue which makes the electrode/tissue interface less favourable for energy transfer to the cardiac muscle, and increases the threshold voltage required to pace the heart. Minute porous alumina ceramic components with a tightly controlled bimodal pore size distribution have been developed to deliver a tiny amount of anti-inflammatory steroid right near the electrode/tissue interface. The pore structure, consisting of a 30% volume fraction of 7μm pores and a 30% volume fraction of 50-7Oμm pores is impregnated with dexamethasone sodium phosphate, which elutes slowly into the tissue near the interface. This device has been shown to be highly effective in reducing the threshold voltage in sheep.en_AU
dc.identifier.citationAnderson, N., Mathivanar, R., Skalsky, M., Drabarek, E., Buykx, W. J., & Reeve, K. D. (1989). Drug elution form porous ceramic components for threshold reduction in pacemaker applications. Presentation to the International Ceramic Conference (AUSTCERAM 90: ceramics technology - sharing the knowledge), Perth, Western Australia, 26-31 August 1990. In Journal of the Australian Ceramic Society, 25(2), 77.en_AU
dc.identifier.conferenceenddate1990-08-31en_AU
dc.identifier.conferencenameInternational Ceramic Conference (AUSTCERAM 90: ceramics technology - sharing the knowledge)en_AU
dc.identifier.conferenceplacePerth, Western Australiaen_AU
dc.identifier.conferencestartdate1990-08-26en_AU
dc.identifier.issn0004-881 Xen_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleJournal of the Australian Ceramic Societyen_AU
dc.identifier.pagination77en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16424en_AU
dc.identifier.volume25en_AU
dc.language.isoenen_AU
dc.publisherTrans Tech Publicationsen_AU
dc.subjectDrug deliveryen_AU
dc.subjectPorosityen_AU
dc.subjectCeramicsen_AU
dc.subjectCardiac Pacemakersen_AU
dc.subjectInflammationen_AU
dc.subjectSteroidsen_AU
dc.subjectSheepen_AU
dc.subjectHearten_AU
dc.titleDrug elution form porous ceramic components for threshold reduction in pacemaker applicationsen_AU
dc.typeConference Abstracten_AU
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