Understanding viral host interactions that modulate nuclear transport and innate immunity
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Date
2021-08-14
Journal Title
Journal ISSN
Volume Title
Publisher
International Union of Crystallography
Abstract
RNA viruses such as coronaviruses, flaviviruses, and henipaviruses represent major international health threats. Whilst these viruses
replicate in the cytoplasm, they encode accessory proteins that target the host nuclear transport machinery to suppress innate immune
pathways. Specifically, these virus proteins target the nuclear import receptor importin-a (IMPa) and inhibit host immune responses
from entering the nucleus and triggering interferon (IFN) release. This immune evasion strategy is a critical component of virus
pathogenicity, yet details of these interactions (including mechanism(s) of binding specificity with IMPa isoforms) remain unresolved.
Here we describe the interfaces between these viral immune regulatory proteins and specific IMPA host receptors as targets for
development of novel antivirals. © The Authors
Description
Keywords
Viruses, Coronaviruses, Viral diseases, Host, Interactions, Health hazards, Cytoplasm, Proteins, Receptors
Citation
Tsimbalyuk, S., Smith, K. M., Edwards, M. R., Cross, E. M., Batra, J., Soares da Costa, T. P., Aragão, D., Basler, C. F., & Forwood, J. K. (2021). Understanding viral host interactions that modulate nuclear transport and innate immunity. Paper presented to the IUCr 2021, 25th Congress of the International Union of Crystallography, 14-22 August 2021, Prague, Czech Republic. In Acta Crystallographica Section A, A77, C98. doi:10.1107/S0108767321095817