Understanding viral host interactions that modulate nuclear transport and innate immunity

Simple item page
dc.contributor.authorTsimbalyuk, Sen_AU
dc.contributor.authorSmith, KMen_AU
dc.contributor.authorEdwards, MRen_AU
dc.contributor.authorCross, EMen_AU
dc.contributor.authorBatra, Jen_AU
dc.contributor.authorSoares da Costa, TPen_AU
dc.contributor.authorAragão, Aen_AU
dc.contributor.authorBasler, CFen_AU
dc.contributor.authorForwood, JKen_AU
dc.date.accessioned2024-04-02T04:38:03Zen_AU
dc.date.available2024-04-02T04:38:03Zen_AU
dc.date.issued2021-08-14en_AU
dc.date.statistics2023-04-18en_AU
dc.description.abstractRNA viruses such as coronaviruses, flaviviruses, and henipaviruses represent major international health threats. Whilst these viruses replicate in the cytoplasm, they encode accessory proteins that target the host nuclear transport machinery to suppress innate immune pathways. Specifically, these virus proteins target the nuclear import receptor importin-a (IMPa) and inhibit host immune responses from entering the nucleus and triggering interferon (IFN) release. This immune evasion strategy is a critical component of virus pathogenicity, yet details of these interactions (including mechanism(s) of binding specificity with IMPa isoforms) remain unresolved. Here we describe the interfaces between these viral immune regulatory proteins and specific IMPA host receptors as targets for development of novel antivirals. © The Authorsen_AU
dc.identifier.citationTsimbalyuk, S., Smith, K. M., Edwards, M. R., Cross, E. M., Batra, J., Soares da Costa, T. P., Aragão, D., Basler, C. F., & Forwood, J. K. (2021). Understanding viral host interactions that modulate nuclear transport and innate immunity. Paper presented to the IUCr 2021, 25th Congress of the International Union of Crystallography, 14-22 August 2021, Prague, Czech Republic. In Acta Crystallographica Section A, A77, C98. doi:10.1107/S0108767321095817en_AU
dc.identifier.conferenceenddate2021-08-22en_AU
dc.identifier.conferencenameIUCr 2021, 25th Congress of the International Union of Crystallographyen_AU
dc.identifier.conferenceplacePrague, Czech Republicen_AU
dc.identifier.conferencestartdate2021-08-14en_AU
dc.identifier.issn2053-2733en_AU
dc.identifier.journaltitleActa Crystallographica Section Aen_AU
dc.identifier.otherMS-09-1en_AU
dc.identifier.paginationC98en_AU
dc.identifier.urihttps://doi.org/doi:10.1107/S0108767321095817en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15542en_AU
dc.identifier.volumeA77en_AU
dc.language.isoenen_AU
dc.publisherInternational Union of Crystallographyen_AU
dc.relation.urihttps://doi.org/doi:10.1107/S0108767321095817en_AU
dc.subjectVirusesen_AU
dc.subjectCoronavirusesen_AU
dc.subjectViral diseasesen_AU
dc.subjectHosten_AU
dc.subjectInteractionsen_AU
dc.subjectHealth hazardsen_AU
dc.subjectCytoplasmen_AU
dc.subjectProteinsen_AU
dc.subjectReceptorsen_AU
dc.titleUnderstanding viral host interactions that modulate nuclear transport and innate immunityen_AU
dc.typeConference Abstracten_AU
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
a59694.pdf
Size:
2.49 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Conference Publications