Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis
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Date
2014-02
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd.
Abstract
Microfluidic systems are currently receiving a lot of attention in the PET radiochemistry field, due to their demonstrated ability to obtain higher incorporation yields with reduced total processing time and using a decreased amount of precursors. The Advion NanoTek LF was the first commercial microfluidic system available for radiochemistry that allows basic parameter optimization to be performed. In this paper we report hardware and software modifications that would allow better performing procedures, higher product throughput and flexibility to utilize the system. In particular, HPLC purification and SPE formulation have been fully integrated. © 2014 Elsevier Ltd.
Description
Keywords
High-performance liquid chromatography, Radioisotopes, Purification, Optimization, Radiochemistry, Production, Positron computed tomography, Dose rates, Parametric analysis, Labelling
Citation
Pascali, G., Berton, A., DeSimone, M., Wyatt, N., Matesic, L., Greguric, I., & Salvadori, P. A. (2014). Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis. Applied Radiation and Isotopes, 84, 40-47. doi:10.1016/j.apradiso.2013.10.020