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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/9021

Title: Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis
Authors: Pascali, G
Berton, A
DeSimone, M
Wyatt, N
Matesic, L
Greguric, I
Salvadori, PA
Keywords: High-performance liquid chromatography
Flourine 18
Purification
Optimization
Radiochemistry
Production
Positron computed tomography
Dose rates
Parametic analysis
Labelling
Issue Date: Feb-2014
Publisher: Elsevier Ltd.
Citation: Pascali, G., Berton, A., DeSimone, M., Wyatt, N., Matesic, L., Greguric, I., & Salvadori, P. A. (2014). Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis. Applied Radiation and Isotopes, 84, 40-47. doi: https://doi.org/10.1016/j.apradiso.2013.10.020
Abstract: Microfluidic systems are currently receiving a lot of attention in the PET radiochemistry field, due to their demonstrated ability to obtain higher incorporation yields with reduced total processing time and using a decreased amount of precursors. The Advion NanoTek LF was the first commercial microfluidic system available for radiochemistry that allows basic parameter optimization to be performed. In this paper we report hardware and software modifications that would allow better performing procedures, higher product throughput and flexibility to utilize the system. In particular, HPLC purification and SPE formulation have been fully integrated. © 2014 Elsevier Ltd.
URI: https://doi.org/10.1016/j.apradiso.2013.10.020
http://apo.ansto.gov.au/dspace/handle/10238/9021
ISSN: 0969-8043
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