Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis

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dc.contributor.authorPascali, Gen_AU
dc.contributor.authorBerton, Aen_AU
dc.contributor.authorDeSimone, Men_AU
dc.contributor.authorWyatt, NAen_AU
dc.contributor.authorMatesic, Len_AU
dc.contributor.authorGreguric, IDen_AU
dc.contributor.authorSalvadori, PAen_AU
dc.date.accessioned2018-09-19T02:20:36Zen_AU
dc.date.available2018-09-19T02:20:36Zen_AU
dc.date.issued2014-02en_AU
dc.date.statistics2018-09-18en_AU
dc.description.abstractMicrofluidic systems are currently receiving a lot of attention in the PET radiochemistry field, due to their demonstrated ability to obtain higher incorporation yields with reduced total processing time and using a decreased amount of precursors. The Advion NanoTek LF was the first commercial microfluidic system available for radiochemistry that allows basic parameter optimization to be performed. In this paper we report hardware and software modifications that would allow better performing procedures, higher product throughput and flexibility to utilize the system. In particular, HPLC purification and SPE formulation have been fully integrated. © 2014 Elsevier Ltd.en_AU
dc.identifier.citationPascali, G., Berton, A., DeSimone, M., Wyatt, N., Matesic, L., Greguric, I., & Salvadori, P. A. (2014). Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis. Applied Radiation and Isotopes, 84, 40-47. doi:10.1016/j.apradiso.2013.10.020en_AU
dc.identifier.govdoc8829en_AU
dc.identifier.issn0969-8043en_AU
dc.identifier.journaltitleApplied Radiation and Isotopesen_AU
dc.identifier.pagination40-47en_AU
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2013.10.020en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9021en_AU
dc.identifier.volume84en_AU
dc.language.isoenen_AU
dc.publisherElsevier Ltd.en_AU
dc.subjectHigh-performance liquid chromatographyen_AU
dc.subjectRadioisotopesen_AU
dc.subjectPurificationen_AU
dc.subjectOptimizationen_AU
dc.subjectRadiochemistryen_AU
dc.subjectProductionen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectDose ratesen_AU
dc.subjectParametric analysisen_AU
dc.subjectLabellingen_AU
dc.titleHardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesisen_AU
dc.typeJournal Articleen_AU
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