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Title: Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part I. Multi-column chromatographic process for clinically applicable
Authors: Le, VS
Morcos, N
Zaw, M
Pellegrini, PA
Greguric, I
Keywords: Lutetium 177
Neutron flux
Extraction chromatography
Issue Date: 1-Sep-2008
Publisher: Springer
Citation: Le., V.S., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I., & Nevissi, A., (2008). Alternative chromatographic processes for no-carrier added Lu-177 radioisotope separation - Part I. Multi-column chromatographic process for clinically applicable. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 663–673. doi:10.1007/s10967-007-7129-8
Abstract: The conventional multi-column solid phase extraction (SPE) chromatography technique using di-(2-ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP) was developed for the separation of no-carrier added (n.c.a) Lu-177 from the bulk quantity of ytterbium target. This technique exploited the large variation of lutetium metal ion distribution coefficients in the varying acidity of the HCl solution-OASIS-HDEHP resin systems for the consecutive loading-eluting cycles performed on different columns. The production batches of several hundred mCi n.c.a Lu-177 radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron nux (Phi = 5 center dot 10(13) were successfully performed using the above mentioned separation technique. With the target irradiation in a reactor of thermal neutron flux Phi = 2 center dot 10(14) or the parallel run of several separation units, many Ci-s of n.c.a Lu-177 can be profitably produced. The OASIS-HDEHP resin based multi-column SPE chromatography technique makes the separation process simple and economic and offers an automation capability for operation in highly radioactive hazardous environments. © 2008, Springer.
Gov't Doc #: 3382
ISSN: 0236-5731
Appears in Collections:Journal Articles

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