Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part I. Multi-column chromatographic process for clinically applicable

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dc.contributor.authorLe, VSen_AU
dc.contributor.authorMorcos, Nen_AU
dc.contributor.authorZaw, Men_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorGreguric, Ien_AU
dc.date.accessioned2011-06-02T04:57:29Zen_AU
dc.date.available2011-06-02T04:57:29Zen_AU
dc.date.issued2008-09-01en_AU
dc.date.statistics2011-06-01en_AU
dc.description.abstractThe conventional multi-column solid phase extraction (SPE) chromatography technique using di-(2-ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP) was developed for the separation of no-carrier added (n.c.a) Lu-177 from the bulk quantity of ytterbium target. This technique exploited the large variation of lutetium metal ion distribution coefficients in the varying acidity of the HCl solution-OASIS-HDEHP resin systems for the consecutive loading-eluting cycles performed on different columns. The production batches of several hundred mCi n.c.a Lu-177 radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron nux (Phi = 5 center dot 10(13) n.cm(-2).s(-1)) were successfully performed using the above mentioned separation technique. With the target irradiation in a reactor of thermal neutron flux Phi = 2 center dot 10(14) n.cm(-2).s(-1) or the parallel run of several separation units, many Ci-s of n.c.a Lu-177 can be profitably produced. The OASIS-HDEHP resin based multi-column SPE chromatography technique makes the separation process simple and economic and offers an automation capability for operation in highly radioactive hazardous environments. © 2008, Springer.en_AU
dc.identifier.citationLe., V.S., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I., & Nevissi, A., (2008). Alternative chromatographic processes for no-carrier added Lu-177 radioisotope separation - Part I. Multi-column chromatographic process for clinically applicable. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 663–673. doi:10.1007/s10967-007-7129-8en_AU
dc.identifier.govdoc3382en_AU
dc.identifier.issn0236-5731en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleJournal of Radioanalytical and Nuclear Chemistryen_AU
dc.identifier.pagination663–673en_AU
dc.identifier.urihttp://dx.doi.org/10.1007/s10967-007-7129-8en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3593en_AU
dc.identifier.volume277en_AU
dc.language.isoenen_AU
dc.publisherSpringeren_AU
dc.subjectLutetium 177en_AU
dc.subjectYtterbiumen_AU
dc.subjectHDEHPen_AU
dc.subjectRadioisotopesen_AU
dc.subjectNeutron fluxen_AU
dc.subjectExtraction chromatographyen_AU
dc.titleAlternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part I. Multi-column chromatographic process for clinically applicableen_AU
dc.typeJournal Articleen_AU
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