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ANSTO Publications Online >
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Please use this identifier to cite or link to this item:
http://apo.ansto.gov.au/dspace/handle/10238/3593
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| Title: | Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation Part I. Multi-column chromatographic process for clinically applicable |
| Authors: | Le, VS Morcos, N Zaw, M Pellegrini, P Greguric, I |
| Keywords: | LUTETIUM 177 YTTERBIUM HDEHP Radioisotopes Neutron Flux Extraction chromatography |
| Issue Date: | 1-Sep-2008 |
| Publisher: | SPRINGER |
| Citation: | Le., V.S., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I., Nevissi, A., (2008). Alternative chromatographic processes for no-carrier added Lu-177 radioisotope separation - Part I. Multi-column chromatographic process for clinically applicable. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 663–673. |
| Abstract: | The conventional multi-column solid phase extraction (SPE) chromatography technique using di-(2-ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP) was developed for the separation of no-carrier added (n.c.a) Lu-177 from the bulk quantity of ytterbium target. This technique exploited the large variation of lutetium metal ion distribution coefficients in the varying acidity of the HCl solution-OASIS-HDEHP resin systems for the consecutive loading-eluting cycles performed on different columns. The production batches of several hundred mCi n.c.a Lu-177 radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron nux (Phi = 5 center dot 10(13) n.cm(-2).s(-1)) were successfully performed using the above mentioned separation technique. With the target irradiation in a reactor of thermal neutron flux Phi = 2 center dot 10(14) n.cm(-2).s(-1) or the parallel run of several separation units, many Ci-s of n.c.a Lu-177 can be profitably produced. The OASIS-HDEHP resin based multi-column SPE chromatography technique makes the separation process simple and economic and offers an automation capability for operation in highly radioactive hazardous environments. © 2008, Springer. |
| URI: | http://dx.doi.org/10.1007/s10967-007-7129-8 http://apo.ansto.gov.au/dspace/handle/10238/3593 |
| ISSN: | 0236-5731 |
| Appears in Collections: | Journal Articles |
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