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Title: [18F]Ethenesulfonyl fluoride as a practical radiofluoride relay reagent
Authors: Zhang, B
Fraser, BH
Klenner, MA
Chen, Z
Liang, SH
Massi, M
Robinson, AJ
Pascali, G
Keywords: Fluorine 18
Labelled compounds
Nuclear medicine
Positron computed tomography
Issue Date: 11-Apr-2019
Publisher: John Wiley & Sons, Inc
Citation: Zhang, B., Fraser, B. H., Klenner, M. A., Chen, Z., Liang, S. H., Massi, M., Robinson, A. J. & Pascali, G. (2019). [18F] Ethenesulfonyl fluoride as a practical radiofluoride relay reagent. Chemistry–A European Journal, 25(32), 7613-7617. doi:10.1002/chem.201900930
Abstract: Fluorine-18 is the most utilized radioisotope in positron emission tomography (PET), but the wide application of fluorine-18 radiopharmaceuticals is hindered by its challenging labelling conditions. As such, many potentially important radiotracers remain underutilized. Herein, we describe the use of [18F]ethenesulfonyl fluoride (ESF) as a novel radiofluoride relay reagent that allows radiofluorination reactions to be performed in minimally equipped satellite nuclear medicine centres. [18F]ESF has a simple and reliable production route and can be stored on inert cartridges. The cartridges can then be shipped remotely and the trapped [18F]ESF can be liberated by simple solvent elution. We have tested 18 radiolabelling precursors, inclusive of model and clinically used structures, and most precursors have demonstrated comparable radiofluorination efficiencies to those obtained using a conventionally dried [18F]fluoride source. © 2019 Wiley-VCH Verlag GmbH & Co.
ISSN: 1521-3765
Appears in Collections:Journal Articles

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