[18F]Ethenesulfonyl fluoride as a practical radiofluoride relay reagent

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dc.contributor.authorZhang, Ben_AU
dc.contributor.authorFraser, BHen_AU
dc.contributor.authorKlenner, MAen_AU
dc.contributor.authorChen, Zen_AU
dc.contributor.authorLiang, SHen_AU
dc.contributor.authorMassi, Men_AU
dc.contributor.authorRobinson, AJen_AU
dc.contributor.authorPascali, Gen_AU
dc.date.accessioned2021-09-14T00:48:51Zen_AU
dc.date.available2021-09-14T00:48:51Zen_AU
dc.date.issued2019-04-11en_AU
dc.date.statistics2021-09-07en_AU
dc.description.abstractFluorine-18 is the most utilized radioisotope in positron emission tomography (PET), but the wide application of fluorine-18 radiopharmaceuticals is hindered by its challenging labelling conditions. As such, many potentially important radiotracers remain underutilized. Herein, we describe the use of [18F]ethenesulfonyl fluoride (ESF) as a novel radiofluoride relay reagent that allows radiofluorination reactions to be performed in minimally equipped satellite nuclear medicine centres. [18F]ESF has a simple and reliable production route and can be stored on inert cartridges. The cartridges can then be shipped remotely and the trapped [18F]ESF can be liberated by simple solvent elution. We have tested 18 radiolabelling precursors, inclusive of model and clinically used structures, and most precursors have demonstrated comparable radiofluorination efficiencies to those obtained using a conventionally dried [18F]fluoride source. © 2019 Wiley-VCH Verlag GmbH & Co.en_AU
dc.description.sponsorshipMonash University. Grant Number: MGS and MIPRS Australian Institute of Nuclear Science and Engineering. Grant Number: PGRA 12074en_AU
dc.identifier.citationZhang, B., Fraser, B. H., Klenner, M. A., Chen, Z., Liang, S. H., Massi, M., Robinson, A. J. & Pascali, G. (2019). [18F] Ethenesulfonyl fluoride as a practical radiofluoride relay reagent. Chemistry – A European Journal, 25(32), 7613-7617. doi:10.1002/chem.201900930en_AU
dc.identifier.issn1521-3765en_AU
dc.identifier.issue32en_AU
dc.identifier.journaltitleChemistry - A European Journalen_AU
dc.identifier.pagination7613-7617en_AU
dc.identifier.urihttps://doi.org/10.1002/chem.201900930en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/11692en_AU
dc.identifier.volume25en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley & Sons, Incen_AU
dc.subjectFluorine 18en_AU
dc.subjectLabelled compoundsen_AU
dc.subjectLabellingen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectNuclear medicineen_AU
dc.subjectRadioisotopesen_AU
dc.subjectPositron computed tomographyen_AU
dc.title[18F]Ethenesulfonyl fluoride as a practical radiofluoride relay reagenten_AU
dc.typeJournal Articleen_AU
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