Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/11329
Title: A fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions
Authors: Klenner, MA
Pascali, G
Zhang, B
Sia, TR
Spare, LK
Krause-Heuer, AM
Aldrich-Wright, JR
Greguric, I
Guastella, AJ
Massi, M
Fraser, BH
Keywords: Fluorine 18
Distillation
Decay
Labelling
Isotopes
Positron computed tomography
Adsorption
Aqueous solutions
Issue Date: 22-Mar-2017
Publisher: John Wiley & Sons, Inc
Citation: Klenner, M. A., Pascali, G., Zhang, B., Sia, T. R., Spare, L. K., Krause-Heuer, A. M., Aldrich-Wright, J. R., Greguric, I., Guastella, A. J., Massi, M., & Fraser, B. H. (2017). A fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions. (2017). Chemistry – A European Journal, 23(27), 6499-6503. doi:10.1002/chem.201700440
Abstract: Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes. © 2017 John Wiley & Sons, Inc
URI: https://doi.org/10.1002/chem.201700440
https://apo.ansto.gov.au/dspace/handle/10238/11329
ISSN: 1521-3765
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.