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|Title:||A fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions|
Positron computed tomography
|Publisher:||John Wiley & Sons, Inc|
|Citation:||Klenner, M. A., Pascali, G., Zhang, B., Sia, T. R., Spare, L. K., Krause-Heuer, A. M., Aldrich-Wright, J. R., Greguric, I., Guastella, A. J., Massi, M., & Fraser, B. H. (2017). A fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions. (2017). Chemistry – A European Journal, 23(27), 6499-6503. doi:10.1002/chem.201700440|
|Abstract:||Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes. © 2017 John Wiley & Sons, Inc|
|Appears in Collections:||Journal Articles|
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