A fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions

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dc.contributor.authorKlenner, MAen_AU
dc.contributor.authorPascali, Gen_AU
dc.contributor.authorZhang, Ben_AU
dc.contributor.authorSia, TRen_AU
dc.contributor.authorSpare, LKen_AU
dc.contributor.authorKrause-Heuer, AMen_AU
dc.contributor.authorAldrich-Wright, JRen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorGuastella, AJen_AU
dc.contributor.authorMassi, Men_AU
dc.contributor.authorFraser, BHen_AU
dc.date.accessioned2021-08-11T06:09:44Zen_AU
dc.date.available2021-08-11T06:09:44Zen_AU
dc.date.issued2017-03-22en_AU
dc.date.statistics2021-08-10en_AU
dc.description.abstractAzeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes. © 2017 John Wiley & Sons, Incen_AU
dc.identifier.citationKlenner, M. A., Pascali, G., Zhang, B., Sia, T. R., Spare, L. K., Krause-Heuer, A. M., Aldrich-Wright, J. R., Greguric, I., Guastella, A. J., Massi, M., & Fraser, B. H. (2017). A fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditions. (2017). Chemistry - A European Journal, 23(27), 6499-6503. doi:10.1002/chem.201700440en_AU
dc.identifier.issn1521-3765en_AU
dc.identifier.issue27en_AU
dc.identifier.journaltitleChemistry - A European Journalen_AU
dc.identifier.pagination6499-6503en_AU
dc.identifier.urihttps://doi.org/10.1002/chem.201700440en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/11329en_AU
dc.identifier.volume23en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley & Sons, Incen_AU
dc.subjectFluorine 18en_AU
dc.subjectDistillationen_AU
dc.subjectDecayen_AU
dc.subjectLabellingen_AU
dc.subjectIsotopesen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectAdsorptionen_AU
dc.subjectAqueous solutionsen_AU
dc.titleA fluorine-18 radiolabeling method enabled by rhenium(I) complexation circumvents the requirement of anhydrous conditionsen_AU
dc.typeJournal Articleen_AU
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