Sulfur - fluorine bond in PET radiochemistry
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Date
2017-07-17
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central Ltd
Abstract
The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications. © The Authors - Creative Commons Attribution 4.0
Description
Keywords
Sulfur, Fluorine, Fluorine 18, Positron computed tomography, Radiochemistry, Molecules, Radiopharmaceuticals
Citation
Pascali, G., Matesic, L., Zhang, B., King, A. T., Robinson, A. J., Ung, A. T. & Fraser, B. H. (2017). Sulfur - fluorine bond in PET radiochemistry. EJNMMI Radiopharmacy and Chemistry, 2(1), 9 (2017). doi:10.1186/s41181-017-0028-6