Sulfur - fluorine bond in PET radiochemistry

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dc.contributor.authorPascali, Gen_AU
dc.contributor.authorMatesic, Len_AU
dc.contributor.authorZhang, Ben_AU
dc.contributor.authorKing, ATen_AU
dc.contributor.authorRobinson, AJen_AU
dc.contributor.authorUng, ATen_AU
dc.contributor.authorFraser, BHen_AU
dc.date.accessioned2021-08-10T06:53:16Zen_AU
dc.date.available2021-08-10T06:53:16Zen_AU
dc.date.issued2017-07-17en_AU
dc.date.statistics2021-08-10en_AU
dc.description.abstractThe importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications. © The Authors - Creative Commons Attribution 4.0en_AU
dc.identifier.citationPascali, G., Matesic, L., Zhang, B., King, A. T., Robinson, A. J., Ung, A. T. & Fraser, B. H. (2017). Sulfur - fluorine bond in PET radiochemistry. EJNMMI Radiopharmacy and Chemistry, 2(1), 9 (2017). doi:10.1186/s41181-017-0028-6en_AU
dc.identifier.issn2365-421Xen_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleEJNMMI Radiopharmacy and Chemistryen_AU
dc.identifier.pagination9en_AU
dc.identifier.urihttps://doi.org/10.1186/s41181-017-0028-6en_AU
dc.identifier.urihttps://apo.ansto.gov.au/dspace/handle/10238/11296en_AU
dc.identifier.volume2en_AU
dc.language.isoenen_AU
dc.publisherBioMed Central Ltden_AU
dc.subjectSulfuren_AU
dc.subjectFluorineen_AU
dc.subjectFluorine 18en_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRadiochemistryen_AU
dc.subjectMoleculesen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.titleSulfur - fluorine bond in PET radiochemistryen_AU
dc.typeJournal Articleen_AU
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