Carborane compounds for neutron capture therapy of malignant melanoma

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dc.contributor.authorWilson, JGen_AU
dc.date.accessioned2025-12-15T06:47:21Zen_AU
dc.date.available2025-12-15T06:47:21Zen_AU
dc.date.issued1992en_AU
dc.date.statistics2025-11-24en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 616.994/17en_AU
dc.description.abstractThe possibility of using thiouracil as a vehicle for stable nuclei such as 10B for neutron capture therapy (NCT) of melanoma was first discussed by Fairchild and co-workers in 1982. The author's research has been directed towards the design and synthesis of a number of o-carboranyl-thiouracils, the ten boron atoms of the carborane cage having a clear advantage for NCT. The first step was the preparation, previously reported, of thiouracils bearing an alkyl group continuing a triple bond for later elaboration to a carborane. The present paper describes the continuation of this work with the preparation of the carboranes of this series and its extension to the synthesis of a thiouracil in which a carboranylalkyl group is attached to the nitrogen in the 3-position. © Plenum Press.en_AU
dc.identifier.citationWilson, J. G. (1992). Carborane compounds for neutron capture therapy of malignant melanoma. Paper presented to the Fourth International Symposium on Neutron Capture Therapy for Cancer, December 4-7, 1990, Sydney, Australia. In B. J. Allen, D. E. Moore, & B. V. Harrington (Eds.), Progress in Neutron Capture Therapy for Cancer (pp. 227-230). Springer US. New Your, USA: Plenum Press.en_AU
dc.identifier.conferenceenddate1990-12-07en_AU
dc.identifier.conferencenameFourth International Symposium on Neutron Capture Therapy for Canceren_AU
dc.identifier.conferenceplaceSydney, Australiaen_AU
dc.identifier.conferencestartdate1990-12-04en_AU
dc.identifier.editorsB. J. Allen, D. E. Moore, & B. V. Harringtonen_AU
dc.identifier.isbn0306441047en_AU
dc.identifier.journaltitleProgress in Neutron Capture Therapy for Canceren_AU
dc.identifier.pagination227-230en_AU
dc.identifier.placeofpublicationNew York, USAen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16797en_AU
dc.language.isoenen_AU
dc.publisherPlenum Pressen_AU
dc.subjectBiological localizationen_AU
dc.subjectBoron 10en_AU
dc.subjectCarboranesen_AU
dc.subjectChemical bondsen_AU
dc.subjectMelanomasen_AU
dc.subjectMolecular structureen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectSynthesisen_AU
dc.subjectThiouracilen_AU
dc.titleCarborane compounds for neutron capture therapy of malignant melanomaen_AU
dc.typeConference Paperen_AU
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