Carborane compounds for neutron capture therapy of malignant melanoma
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Date
1992
Authors
Journal Title
Journal ISSN
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Publisher
Plenum Press
Abstract
The possibility of using thiouracil as a vehicle for stable nuclei such as 10B for neutron capture therapy (NCT) of melanoma was first discussed by Fairchild and co-workers in 1982. The author's research has been directed towards the design and synthesis of a number of o-carboranyl-thiouracils, the ten boron atoms of the carborane cage having a clear advantage for NCT. The first step was the preparation, previously reported, of thiouracils bearing an alkyl group continuing a triple bond for later elaboration to a carborane. The present paper describes the continuation of this work with the preparation of the carboranes of this series and its extension to the synthesis of a thiouracil in which a carboranylalkyl group is attached to the nitrogen in the 3-position. © Plenum Press.
Description
Physical copy held by ANSTO Library at DDC: 616.994/17
Keywords
Biological localization, Boron 10, Carboranes, Chemical bonds, Melanomas, Molecular structure, Neutron capture therapy, Synthesis, Thiouracil
Citation
Wilson, J. G. (1992). Carborane compounds for neutron capture therapy of malignant melanoma. Paper presented to the Fourth International Symposium on Neutron Capture Therapy for Cancer, December 4-7, 1990, Sydney, Australia. In B. J. Allen, D. E. Moore, & B. V. Harrington (Eds.), Progress in Neutron Capture Therapy for Cancer (pp. 227-230). Springer US. New Your, USA: Plenum Press.