Morphological changes in human melanoma cells following irradiation with thermal neutrons

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dc.contributor.authorBarkala, DKen_AU
dc.contributor.authorAllen, BJen_AU
dc.contributor.authorBrown, JKen_AU
dc.contributor.authorMountford, Men_AU
dc.contributor.authorMishima, Yen_AU
dc.contributor.authorIchihashi, Men_AU
dc.date.accessioned2025-11-21T06:46:31Zen_AU
dc.date.available2025-11-21T06:46:31Zen_AU
dc.date.issued1989en_AU
dc.date.statistics2025-11-12en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 616.99477/3 Also held as part of a journal Pigment Cell Research Vol. 2, No. 4 (1989) at the same DDC number.en_AU
dc.description.abstractMorphological changes in two human melanoma cell lines, MM96 and MM418, following irradiation with thermal neutrons, were studied using light and electron microscopy. The results show that the response of human malignant melanoma cells to neutron irradiation is both cell line dependent and dose dependent, and that in any given cell line, some cells are more resistant to irradiation than others, thus demonstrating heterogeneity in respect to radiosensitivity. Cells repopulating MM96 flasks after irradiation were morphologically similar to the cells of origin whereas in MM418 flasks cells differentiated into five morphologically distinct subgroups and showed increased melanization. The results also show that radiation causes distinctive morphological patterns of damage although ultrastructural changes unique to the high LET particles released from boron 10 neutron capture are yet to be identified. © Alan R. Liss Inc.en_AU
dc.identifier.booktitleMelanoma neutron capture therapy : proceedings of 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987en_AU
dc.identifier.citationBarkla, D. H., Allen, B. J., Brown, J. K., Mountford, M., Mishima, Y., & Ichihashi, M. (1989). Morphological changes in human melanoma cells following irradiation with thermal neutrons. Paper prsented to the 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987. In Mishima, Y. (ed.). Melanoma neutron capture therapy : proceedings of 2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, September 23-26, 1987, (pp. 345-348). New York : Alan R. Liss.en_AU
dc.identifier.conferenceenddate1987-09-26en_AU
dc.identifier.conferencename2nd Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanomaen_AU
dc.identifier.conferenceplaceKobeen_AU
dc.identifier.conferencestartdate1987-09-23en_AU
dc.identifier.editorsYukata Mishimaen_AU
dc.identifier.issn0893-5785en_AU
dc.identifier.pagination345-348en_AU
dc.identifier.placeofpublicationNew Worken_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16729en_AU
dc.language.isoenen_AU
dc.publisherAlan R. Liss, Incen_AU
dc.relation.ispartofseriesSINCT-REP; 1en_AU
dc.subjectAmino acidsen_AU
dc.subjectAnimal cellsen_AU
dc.subjectAnimalsen_AU
dc.subjectAromaticsen_AU
dc.subjectBoron compoundsen_AU
dc.subjectDose-response relationshipsen_AU
dc.subjectElectron microscopyen_AU
dc.subjectMelanomasen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectNeutronsen_AU
dc.subjectPhenylalanineen_AU
dc.subjectRBEen_AU
dc.subjectTumor cellsen_AU
dc.subjectUltrastructural changesen_AU
dc.subjectRadiotherapyen_AU
dc.subjectTherapyen_AU
dc.titleMorphological changes in human melanoma cells following irradiation with thermal neutronsen_AU
dc.typeConference Paperen_AU
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