Dose quantification in carbon ion therapy using in-beam positron emission tomography

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dc.contributor.authorRutherford, Hen_AU
dc.contributor.authorChacon, Aen_AU
dc.contributor.authorMohammadi, Aen_AU
dc.contributor.authorTakyu, Sen_AU
dc.contributor.authorTashima, Hen_AU
dc.contributor.authorYoshida, Een_AU
dc.contributor.authorNishikido, Fen_AU
dc.contributor.authorHofmann, Ten_AU
dc.contributor.authorPinto, Men_AU
dc.contributor.authorFranklin, DRen_AU
dc.contributor.authorYamaya, Ten_AU
dc.contributor.authorParodi, Ken_AU
dc.contributor.authorRosenfeld, ABen_AU
dc.contributor.authorGuatelli, Sen_AU
dc.contributor.authorSafavi-Naeini, Men_AU
dc.date.accessioned2025-01-10T01:04:02Zen_AU
dc.date.available2025-01-10T01:04:02Zen_AU
dc.date.issued2020-12-07en_AU
dc.date.statistics2024-10-23en_AU
dc.description.abstractThis work presents an iterative method for the estimation of the absolute dose distribution in patients undergoing carbon ion therapy, via analysis of the distribution of positron annihilations resulting from the decay of positron-emitting fragments created in the target volume. The proposed method relies on the decomposition of the total positron-annihilation distributions into profiles of the three principal positron-emitting fragment species - 11C, 10C and 15O. A library of basis functions is constructed by simulating a range of monoenergetic 12C ion irradiations of a homogeneous polymethyl methacrylate phantom and measuring the resulting one-dimensional positron-emitting fragment profiles and dose distributions. To estimate the dose delivered during an arbitrary polyenergetic irradiation, a linear combination of factors from the fragment profile library is iteratively fitted to the decomposed positron annihilation profile acquired during the irradiation, and the resulting weights combined with the corresponding monoenergetic dose profiles to estimate the total dose distribution. A total variation regularisation term is incorporated into the fitting process to suppress high-frequency noise. The method was evaluated with 14 different polyenergetic 12C dose profiles in a polymethyl methacrylate target: one which produces a flat biological dose, 10 with randomised energy weighting factors, and three with distinct dose maxima or minima within the spread-out Bragg peak region. The proposed method is able to calculate the dose profile with mean relative errors of 0.8%, 1.0% and 1.6% from the 11C, 10C, 15O fragment profiles, respectively, and estimate the position of the distal edge of the SOBP to within an average of 0.7 mm, 1.9 mm and 1.2 mm of its true location. © 2020 Commonwealth of Australia, ANSTOen_AU
dc.description.sponsorshipThis research is supported by the Australian Government Research Training Program (AGRTP) scholarship and the AINSE Honours Scholarship Program. The authors would like to thank AINSE Limited for providing financial assistance (Award - Residential Student Scholarship 2018) to enable work on this research. This research was undertaken with the assistance of resources from the National Computational Infrastructure (NCI Australia), an NCRIS enabled capability supported by the Australian Government. This work was supported by the Multi-modal Australian ScienceS Imaging and Visualisation Environment (MASSIVE).en_AU
dc.format.mediumElectronicen_AU
dc.identifier.articlenumber235052en_AU
dc.identifier.citationRutherford, H., Chacon, A., Mohammadi, A., Takyu, S., Tashima, H., Yoshida, E., Nishikido, F., Hofmann, T., Pinto, M., Franklin, D. R., Yamaya, T., Parodi, K., Rosenfeld, A. B., Guatelli, S., & Safavi-Naeini, M. (2020). Dose quantification in carbon ion therapy using in-beam positron emission tomography. Physics in Medicine & Biology, 65(23), 235052. doi:10.1088/1361-6560/abaa23en_AU
dc.identifier.issn0031-9155en_AU
dc.identifier.issn1361-6560en_AU
dc.identifier.issue23en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.urihttps://doi.org/10.1088/1361-6560/abaa23en_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/15891en_AU
dc.identifier.volume65en_AU
dc.languageengen_AU
dc.language.isoenen_AU
dc.publisherIOP Publishingen_AU
dc.subjectCarbonen_AU
dc.subjectDosesen_AU
dc.subjectIonsen_AU
dc.subjectTomographyen_AU
dc.subjectPositronsen_AU
dc.subjectDecayen_AU
dc.subjectPatientsen_AU
dc.subjectPositron annihilation spectroscopyen_AU
dc.subjectRadiation dose distributionsen_AU
dc.titleDose quantification in carbon ion therapy using in-beam positron emission tomographyen_AU
dc.typeJournal Articleen_AU
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