Local control of murine melanoma xenografts in nude mice by neutron capture therapy

Simple item page
dc.contributor.authorAllen, BJen_AU
dc.contributor.authorCorderoy-Buck, Sen_AU
dc.contributor.authorMeriaty, Hen_AU
dc.contributor.authorMoore, DEen_AU
dc.date.accessioned2025-11-24T06:49:33Zen_AU
dc.date.available2025-11-24T06:49:33Zen_AU
dc.date.issued1989-10-02en_AU
dc.date.statistics2025-11-12en_AU
dc.descriptionPhysical copy held by ANSTO Library at DDC: 571.45/15en_AU
dc.description.abstractThe systemic administration of enriched B-BPA results in selective uptake by melanoma xenografts in the nude mouse model. The boron-10, located in the tumour cells, acts as a radiation sensitiser for thermal neutron irradiation. The effect of 10BPA as a neutron sensitiser is clearly observed for the first time in the nude mouse model for a tumour cure endpoint when an incident neutron fluence of 1.1 x 1013n cm is combined with an average of 30 ppm enriched boron-10 concentration in the tumour. A therapeutic gain of 6 is achieved. The NCT treated mice have been observed for more than 200 days. Tumour recurrence was observed at 30 and 200 days. There is no evidence in our experiments to suggests that tumour cures can be ascribed to the neutrons alone. As a consequence, we have demonstrated that the nude mouse model is a viable model for testing the efficacy of neutron capture therapy. In the case of the Harding-Passey melanoma xenograft model, we have shown that a single NCT treatment can bring about complete local control, without inducing significant skin damage. Complete local control is a manifestation of the high LET radiation released after neutron capture by boron-10, and does not result from a equal fluence of neutrons alone. © The Authorsen_AU
dc.identifier.booktitle13th AINSE Radiation Biology Conference, 2-4 October 1991, Lucas Heights - AINSE Theatre : conference handbook (programme, abstracts and general information)en_AU
dc.identifier.citationAllen, B. J., Corderoy-Buck, S., Meriaty, H., & Moore, D. E. (1991). Local control of murine melanoma xenografts in nude mice by neutron capture therapy. Presentation to the 13th AINSE Radiation Biology Conference, 2-4 October 1991, Lucas Heights - AINSE Theatre : conference handbook (programme, abstracts and general information), (pp.12). Lucas Heights, New South Wales : AINSE.en_AU
dc.identifier.conferenceenddate1991-10-04en_AU
dc.identifier.conferencename13th AINSE Radiation Biology Conferenceen_AU
dc.identifier.conferenceplaceLucas Heights, New South Walesen_AU
dc.identifier.conferencestartdate1991-10-02en_AU
dc.identifier.pagination12en_AU
dc.identifier.placeofpublicationLucas Heights, New South Walesen_AU
dc.identifier.urihttps://apo.ansto.gov.au/handle/10238/16738en_AU
dc.language.isoenen_AU
dc.publisherAINSEen_AU
dc.subjectBiological modelsen_AU
dc.subjectBoron 10en_AU
dc.subjectExperimental neoplasmsen_AU
dc.subjectLabelled compoundsen_AU
dc.subjectMelanomasen_AU
dc.subjectMiceen_AU
dc.subjectNeutron capture therapyen_AU
dc.subjectTumor cellsen_AU
dc.titleLocal control of murine melanoma xenografts in nude mice by neutron capture therapyen_AU
dc.typeConference Abstracten_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Conference Publications