Local control of murine melanoma xenografts in nude mice by neutron capture therapy

Allen, BJ; Corderoy-Buck, S; Meriaty, H; Moore, DE

Local control of murine melanoma xenografts in nude mice by neutron capture therapy

Date

1989-10-02

Authors

Publisher

AINSE

Abstract

The systemic administration of enriched B-BPA results in selective uptake by melanoma xenografts in the nude mouse model. The boron-10, located in the tumour cells, acts as a radiation sensitiser for thermal neutron irradiation. The effect of 10BPA as a neutron sensitiser is clearly observed for the first time in the nude mouse model for a tumour cure endpoint when an incident neutron fluence of 1.1 x 1013n cm is combined with an average of 30 ppm enriched boron-10 concentration in the tumour. A therapeutic gain of 6 is achieved. The NCT treated mice have been observed for more than 200 days. Tumour recurrence was observed at 30 and 200 days. There is no evidence in our experiments to suggests that tumour cures can be ascribed to the neutrons alone. As a consequence, we have demonstrated that the nude mouse model is a viable model for testing the efficacy of neutron capture therapy. In the case of the Harding-Passey melanoma xenograft model, we have shown that a single NCT treatment can bring about complete local control, without inducing significant skin damage. Complete local control is a manifestation of the high LET radiation released after neutron capture by boron-10, and does not result from a equal fluence of neutrons alone. © The Authors

Description

Physical copy held by ANSTO Library at DDC: 571.45/15

Keywords

Biological models, Boron 10, Experimental neoplasms, Labelled compounds, Melanomas, Mice, Neutron capture therapy, Tumor cells

Citation

Allen, B. J., Corderoy-Buck, S., Meriaty, H., & Moore, D. E. (1991). Local control of murine melanoma xenografts in nude mice by neutron capture therapy. Presentation to the 13th AINSE Radiation Biology Conference, 2-4 October 1991, Lucas Heights - AINSE Theatre : conference handbook (programme, abstracts and general information), (pp.12). Lucas Heights, New South Wales : AINSE.