Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands

Pages, BJ; Sakoff, J; Gilbert, J; Zhang, Y; Li, F; Preston, D; Crowley, JD; Aldrich-Wright, JR

Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands

Date

2016-12-01

Authors

Publisher

Elsevier B.V.

Abstract

Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine. © 2016 Elsevier B.V.

Keywords

Platinum, Triazoles, Growth, Crystal structure, Crystallography, Nuclear magnetic resonance, Spectroscopy, Pyridine, In vitro, X-ray diffraction, Ligands

Citation

Pages, B. J., Sakoff, J., Gilbert, J., Zhang, Y., Li, F., Preston, D., Cowley, J. D., & Aldrich-Wright, J. R. (2016). Investigating the cytotoxicity of platinum (II) complexes incorporating bidentate pyridyl-1, 2, 3-triazole “click” ligands. Journal of Inorganic Biochemistry, 165, 92-99. doi:10.1016/j.jinorgbio.2016.06.017