Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction

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dc.contributor.authorTarn, MDen_AU
dc.contributor.authorPascali, Gen_AU
dc.contributor.authorDe Leonardis, Fen_AU
dc.contributor.authorWatts, Pen_AU
dc.contributor.authorSalvadori, PAen_AU
dc.contributor.authorPamme, Nen_AU
dc.date.accessioned2018-09-19T04:50:53Zen_AU
dc.date.available2018-09-19T04:50:53Zen_AU
dc.date.issued2013-03-08en_AU
dc.date.statistics2018-09-18en_AU
dc.description.abstractMicrofluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [18F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [18F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value. © 2013 Elsevier B.V.en_AU
dc.identifier.citationTarn, M. D., Pascali, G., De Leonardis, F., Watts, P., Salvadori, P. A., & Pamme, N. (2013). Purification of 2-[18 F] fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction. Journal of Chromatography A, 1280, 117-121. doi:10.1016/j.chroma.2013.01.032en_AU
dc.identifier.govdoc8882en_AU
dc.identifier.issn0021-9673en_AU
dc.identifier.journaltitleJournal of Chromatography Aen_AU
dc.identifier.pagination117-121en_AU
dc.identifier.urihttps://doi.org/10.1016/j.chroma.2013.01.032en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9026en_AU
dc.identifier.volume1280en_AU
dc.language.isoenen_AU
dc.publisherElsevier B.V.en_AU
dc.subjectFluorine 18en_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectPurificationen_AU
dc.subjectTracer techniquesen_AU
dc.subjectResinsen_AU
dc.titlePurification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extractionen_AU
dc.typeJournal Articleen_AU
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