Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction
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Date
2013-03-08
Journal Title
Journal ISSN
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Publisher
Elsevier B.V.
Abstract
Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [18F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [18F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value. © 2013 Elsevier B.V.
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Keywords
Fluorine 18, Positron computed tomography, Radiopharmaceuticals, Purification, Tracer techniques, Resins
Citation
Tarn, M. D., Pascali, G., De Leonardis, F., Watts, P., Salvadori, P. A., & Pamme, N. (2013). Purification of 2-[18 F] fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction. Journal of Chromatography A, 1280, 117-121. doi:10.1016/j.chroma.2013.01.032