Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts

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dc.contributor.authorPascali, Gen_AU
dc.contributor.authorDel Carlo, Sen_AU
dc.contributor.authorRocchiccioli, Sen_AU
dc.contributor.authorSignore, Gen_AU
dc.contributor.authorSaccomanni, Gen_AU
dc.contributor.authorManera, Cen_AU
dc.contributor.authorMacchia, Men_AU
dc.contributor.authorSalvadori, PAen_AU
dc.date.accessioned2018-09-17T05:59:32Zen_AU
dc.date.available2018-09-17T05:59:32Zen_AU
dc.date.issued2014-08-24en_AU
dc.date.statistics2018-09-16en_AU
dc.description.abstractThe use of direct radiofluorination of aryliodonium salts represents a promising route to new PET tracers. This study tested the use of these precursors for obtaining candidate ligands of the cannabinoid type-2 receptor. 18F-labelling was performed using microfluidic technology, which allowed obtaining good incorporation yields. A closer inspection of the chemical composition of the reaction mixture evidenced the recurrent occurrence of chemical byproducts (H-adduct) due to a reductive side reaction of these substrates. The H-adduct formation seems to be unrelated to water presence, needed for obtaining a satisfactory incorporation, and may become an important feature for assessing the real-life accessibility of new radiotracers through the use of aryliodonium precursors. © 2014 Akadémiai Kiadó, Budapest, Hungaryen_AU
dc.identifier.citationPascali, G., Del Carlo, S., Rocchiccioli, S., Signore, G., Saccomanni, G., Manera, C., Macchia, M., & Salvadori, P. A. (2015). Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts. Journal of Radioanalytical and Nuclear Chemistry, 303(1), 1021-1027. doi:10.1007/s10967-014-3407-4en_AU
dc.identifier.govdoc8842en_AU
dc.identifier.issn1588-2780en_AU
dc.identifier.issue31en_AU
dc.identifier.journaltitleJournal of Radioanalytical and Nuclear Chemistryen_AU
dc.identifier.pagination1021-1027en_AU
dc.identifier.urihttps://doi.org/10.1007/s10967-014-3407-4en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9010en_AU
dc.identifier.volume30en_AU
dc.language.isoenen_AU
dc.publisherSpringer Natureen_AU
dc.subjectSaltsen_AU
dc.subjectFluidsen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectIsotopesen_AU
dc.subjectRadiochemistryen_AU
dc.subjectNuclear magnetic resonanceen_AU
dc.subjectLigandsen_AU
dc.subjectHigh-performance liquid chromatographyen_AU
dc.titleIdentification of chemical byproducts in the radiofluorination of structurally complex aryliodonium saltsen_AU
dc.typeJournal Articleen_AU
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