Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts

Pascali, G; Del Carlo, S; Rocchiccioli, S; Signore, G; Saccomanni, G; Manera, C; Macchia, M; Salvadori, PA

Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts

Date

2014-08-24

Authors

Publisher

Springer Nature

Abstract

The use of direct radiofluorination of aryliodonium salts represents a promising route to new PET tracers. This study tested the use of these precursors for obtaining candidate ligands of the cannabinoid type-2 receptor. 18F-labelling was performed using microfluidic technology, which allowed obtaining good incorporation yields. A closer inspection of the chemical composition of the reaction mixture evidenced the recurrent occurrence of chemical byproducts (H-adduct) due to a reductive side reaction of these substrates. The H-adduct formation seems to be unrelated to water presence, needed for obtaining a satisfactory incorporation, and may become an important feature for assessing the real-life accessibility of new radiotracers through the use of aryliodonium precursors. © 2014 Akadémiai Kiadó, Budapest, Hungary

Keywords

Salts, Fluids, Positron computed tomography, Isotopes, Radiochemistry, Nuclear magnetic resonance, Ligands, High-performance liquid chromatography

Citation

Pascali, G., Del Carlo, S., Rocchiccioli, S., Signore, G., Saccomanni, G., Manera, C., Macchia, M., & Salvadori, P. A. (2015). Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts. Journal of Radioanalytical and Nuclear Chemistry, 303(1), 1021-1027. doi:10.1007/s10967-014-3407-4