Imaging capabilities of the Inveon SPECT system using single-and multipinhole collimators

Simple item page
dc.contributor.authorBoisson, Fen_AU
dc.contributor.authorZahra, Den_AU
dc.contributor.authorParmar, Aen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorMeikle, SRen_AU
dc.contributor.authorHamze, Hen_AU
dc.contributor.authorReilhac, Aen_AU
dc.date.accessioned2020-02-13T06:07:09Zen_AU
dc.date.available2020-02-13T06:07:09Zen_AU
dc.date.issued2013-09-05en_AU
dc.date.statistics2019-11-21en_AU
dc.description.abstractThe Inveon small-animal SPECT system comes with several types of multipinhole collimator plates. We evaluate here the performance measurements of the Inveon SPECT system using 6 different collimators: 3 dedicated for mouse imaging and 3 for rat imaging. Methods: The measured performance parameters include the sensitivity, the spatial resolution using line sources, the ultra-micro Derenzo phantom, the recovery coefficient and the noise measurements using the National Electrical Manufacturers Association NU-4 image quality phantom, obtained with the 2 reconstruction algorithms available with the Inveon Acquisition Workplace, version 1.5—the 3-dimensional ordered-subset expectation maximization (3DOSEM) and the 3-dimensional maximum a posteriori (3DMAP). Further, the overall performance of the system is illustrated by an animal experiment. Results: The results show that the Inveon SPECT scanner offers a spatial resolution, measured at the center of the field of view, ranging from 0.6 to 1 mm with the collimator plates dedicated to mouse imaging and from 1.2 to less than 2 mm with rat collimator plates. The system sensitivity varies from 29 to 404 cps/MBq for mouse collimators and from 53 to 175 cps/MBq for rat collimators. The image quality study showed that 3DMAP allows better noise reduction while preserving the recovery coefficient, compared with other regularization strategies such as the premature termination of the 3DOSEM reconstruction or 3DOSEM followed by gaussian filtering. Conclusion: The acquisition parameters, such as the collimator set and the radius of rotation, offer a wide range of possibilities to apply to a large number of biologic studies. However, special care must be taken because this increase in sensitivity can be offset by image degradation, such as image artifacts caused by projection overlap and statistical noise due to a higher number of iterations required for convergence. 3DMAP allowed better noise reduction while maintaining relatively constant recovery coefficients, as compared with other reconstruction strategies. © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.en_AU
dc.identifier.citationBoisson, F., Zahra, D., Parmar, A., Grégoire, M. C., Meikle, S. R., Hamse, H., & Reilhac, A. (2013). Imaging capabilities of the Inveon SPECT system using single-and multipinhole collimators. Journal of Nuclear Medicine, 54(10), 1833-1840. doi:10.2967/jnumed.112.117572en_AU
dc.identifier.govdoc8681en_AU
dc.identifier.issn2159-662Xen_AU
dc.identifier.issue10en_AU
dc.identifier.journaltitleJournal of Nuclear Medicineen_AU
dc.identifier.pagination1833-1840en_AU
dc.identifier.urihttp://doi.org/10.2967/jnumed.112.117572en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9113en_AU
dc.identifier.volume54en_AU
dc.language.isoenen_AU
dc.publisherSociety of Nuclear Medicine and Molecular Imagingen_AU
dc.subjectImagesen_AU
dc.subjectImage scannersen_AU
dc.subjectSingle photon emission computed tomographyen_AU
dc.subjectAnimalsen_AU
dc.subjectCollimatorsen_AU
dc.subjectSensitivityen_AU
dc.titleImaging capabilities of the Inveon SPECT system using single-and multipinhole collimatorsen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles