Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

Sigma2 (σ2) receptors are highly expressed in cancer cell lines and in tumours. Two novel selective 18F-phthalimido σ2 ligands, 18F-SIG343 and 18F-SIG353, were prepared and characterised for their potential tumour imaging properties. © 2013 Nguyen et al.; licensee Springer.

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In vivo, Proteins, Receptors, Neoplasms, Channeling, Tracer techniques, Metabolites

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Nguyen, V. H., Pham, T., Fookes, C., Berghofer, P., Greguric, I., Arthur, A., Mattner, F., Rahardjo, G., Davis, E., Howell, N., Grégoire M. C., Katsifis, A., & Shepherd, R. (2013). Synthesis and biological characterisation of 18 F-SIG343 and 18 F-SIG353, novel and high selectivity σ 2 radiotracers, for tumour imaging properties. EJNMMI Research, 3(1), 80. doi:10.1186/2191-219X-3-80

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https://doi.org/10.1186/2191-219X-3-80
http://apo.ansto.gov.au/dspace/handle/10238/9016

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Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

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