An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer

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dc.contributor.authorRajkamal, Ben_AU
dc.contributor.authorDutta, NKen_AU
dc.contributor.authorChoudhury, NRen_AU
dc.contributor.authorElvin, CMen_AU
dc.contributor.authorLyon, REen_AU
dc.contributor.authorKnott, RBen_AU
dc.contributor.authorHill, AJen_AU
dc.date.accessioned2016-03-24T02:48:38Zen_AU
dc.date.available2016-03-24T02:48:38Zen_AU
dc.date.issued2014-11-01en_AU
dc.date.statistics2016-03-24en_AU
dc.description.abstractEngineered protein polymers that display responsiveness to multiple stimuli are emerging as a promising class of soft material with unprecedented functionality. The remarkable advancement in genetic engineering and biosynthesis has created the opportunity for precise control over the amino acid sequence, size, structure and resulting functions of such biomimetic proteins. Herein, we describe the multi-stimuli-responsive characteristics of a resilin-mimetic protein, An16-resilin (An16), derived from the consensus sequence of resilin gene in the mosquito Anopheles gambiae. We demonstrate that An16 is an intrinsically disordered protein that displays unusual dual-phase thermal transition behavior along with responsiveness to pH, ion, light and humidity. Identifying the molecular mechanisms that allow An16 to sense and switch in response to varying environments furthers the ability to design intelligent biomacromolecules. © 2014 Acta Materialia Inc.en_AU
dc.identifier.citationBalu, R., Dutta, N. K., Choudhury, N. R., Elvin, C. M., Lyons, R. E., Knott, R., & Hill, A. J. (2014). An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer. Acta Biomaterialia, 10(11), 4768-4777. doi:10.1016/j.actbio.2014.07.030en_AU
dc.identifier.govdoc6523en_AU
dc.identifier.issn1742-7061en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleActa Biomaterialiaen_AU
dc.identifier.pagination4768-4777en_AU
dc.identifier.urihttps://doi.org/10.1016/j.actbio.2014.07.030en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6660en_AU
dc.identifier.volume10en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectProteinsen_AU
dc.subjectPolymersen_AU
dc.subjectGenetic engineeringen_AU
dc.subjectAmino acidsen_AU
dc.subjectMoleculesen_AU
dc.titleAn16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymeren_AU
dc.typeJournal Articleen_AU
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