Chemical synthesis and application of zirconium and titanium polymer compounds for the preparation of Tc-99m and Re-188 chromtographic generators

Abstract

PZC adsorbent for the preparation of PZC based chromatographic Tc-99m and / or Re-188 generators was successfully synthesized and its chemical composition, molecular structure was determined. 99Mo and/or 188W -adsorption on PZC in different solutions and 99mTc and/or 188Re elution from PZC columns were investigated. Mo- adsorption capacity of about 285 mgMo/gPZC and Tc-99m elution yield of higher than 90% were achieved with PZC adsorbent. Mo-99 breakthrough of 0.015% and Molybdenum element breakthrough of lower than 5μg Mo/ml were found in Tc-99m eluate. W- adsorption capacity of about 520 mgW/gPZC and Re-188 elution yield of higher than 80% were also achieved with PZC adsorbent. W-188 breakthrough of 0.015% and Tungsten element breakthrough of lower than 5 μg W /ml were found in Tc-99m eluate. A good relationship between the W- or Mo-content of adsorption solution and the adsorption capacity, adsorption percentage, chemical breakthrough and relevant radionuclide elution yield was found.