Chemical synthesis and application of zirconium and titanium polymer compounds for the preparation of Tc-99m and Re-188 chromtographic generators
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Date
2006-04-03
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IAEA’S coordinated research project 2nd research coordination meeting
Abstract
PZC adsorbent for the preparation of PZC based chromatographic Tc-99m and / or Re-188 generators was successfully synthesized and its chemical composition, molecular structure was determined. 99Mo and/or 188W -adsorption on PZC in different solutions and 99mTc and/or 188Re elution from PZC columns were investigated. Mo- adsorption capacity of about 285 mgMo/gPZC and Tc-99m elution yield of higher than 90% were achieved with PZC adsorbent. Mo-99 breakthrough of 0.015% and Molybdenum element breakthrough of lower than 5μg Mo/ml were found in Tc-99m eluate.
W- adsorption capacity of about 520 mgW/gPZC and Re-188 elution yield of higher than 80% were also achieved with PZC adsorbent. W-188 breakthrough of 0.015% and Tungsten element breakthrough of lower than 5 μg W /ml were found in Tc-99m eluate.
A good relationship between the W- or Mo-content of adsorption solution and the adsorption capacity, adsorption percentage, chemical breakthrough and relevant radionuclide elution yield was found.
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Keywords
Radioisotope generators, Titanium compounds, Molybdenum 99, Zirconium compounds, Radioisotope generators, Chemical preparation
Citation
Le V.S. (2006). Chemical synthesis and application of zirconium and titanium polymer compounds for the preparation of Tc-99m and Re-188 chromtographic generators. Paper presented to the IAEA’S coordinated research project 2nd research co-nation meeting. "Development of generator technologies for therapeutic radionuclides”, 3th-7th April. European Institute of Oncology, Milan, Italy.