Development of alternative technologies for a gel-type chromatographic Tc-99m generator

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dc.contributor.authorLe, VSen_AU
dc.contributor.authorLambrecht, RMen_AU
dc.date.accessioned2011-07-28T01:45:24Zen_AU
dc.date.available2011-07-28T01:45:24Zen_AU
dc.date.issued1994-04-01en_AU
dc.date.statistics2011-07-28en_AU
dc.description.abstractThere is continuing concern worldwide about the need for multiple sources of the 99Mo generator, and the large investment required to introduce the use of 235U (n, f) 99Mo derived production at a mew facility. This is sufficient justification required for research on the development of technologies for a gel-type chromatographic 99mTc generator based on the 98Mo(n,r)99 Mo nuclear reaction. The synthesis of Titanium-Molybdate (abbrev. TiMo) generator packing gel pre-formed for 98Mo(n,r)99 Mo neutron activation of TiMo; and Zirconium-Molybdate (abbrev. ZrMo) gel columns containing (n,r) produced 99Mo for preparation of chromatographic 98mTc generators was studied. The chemistry of polymerisation, and amorphous or crystalline TiMo and ZrMo formating of the molybdate polyanion was investigated for the interpretation of the 99mTc-elution performance from the gel generators. Preparatory conditions of TiMo and ZrMo were found to be very critical. The complexity in the preparation of TiMo and ZrMo is attributed to the large capability of polymeric hydroxl complexes of Ti+4 and Zr+4 ions in the aqueous solution. The preparation of TiMo and ZrMo requires a process of high standardisation to give a product of consistent quality. X-ray diffraction patterns of the MoTi gel were similar between batches. Behaviours, such as target temperature, irradiation stability, and neutron self-shielding, of the TiMo gel under reactor irradiation conditions that effect the performance of the generator and the quality of the 99mTc pertechnetate elucate were measured. The specifications of TiMo and ZiMo gel columns of high 99mTc elution performance, and chromatographic 99mTc generator options yielding 99mTc fulfilling the requirements for nuclear medicine applications with several conventional kits will be illustratively described. The eluents used in the generator options are saline, redistilled water, or even organic solvent such as acetone, MEK. Fifty gel generators this type were tested in different hospitals in Vietnam, and gave satifactory results. The gel generator concept is particularly relevant to hospitals in developing countries that do not have access to fission produced 99Mo generators. Also a satisfactory gel-type generator based on (n,r)99 Mo Should be economical to produce. © 1994, Wiley-Blackwellen_AU
dc.identifier.citationLe, V.S., Lambrecht, R. M. (1994). Development of alternative technologies for a gel-type chromatographic Tc-99 generator. Presentation to the 10th International Symposium on Radiopharmaceutical Chemistry, 25th-28th Oct 1993, Kyoto, Japan, In Journal of Labelled Compounds and Radiopharmaceuticals, 35(S1), 270-272en_AU
dc.identifier.conferenceenddate28 October 1993en_AU
dc.identifier.conferencename10th International Symposium on Radiopharmaceutical Chemistryen_AU
dc.identifier.conferenceplaceKyoto, Japanen_AU
dc.identifier.conferencestartdate25 October 1993en_AU
dc.identifier.govdoc3386en_AU
dc.identifier.issn1099-1344en_AU
dc.identifier.issueS1en_AU
dc.identifier.journaltitleJournal of Labelled Compounds and Radiopharmaceuticalsen_AU
dc.identifier.pagination270-272en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3629en_AU
dc.identifier.volume35en_AU
dc.language.isoenen_AU
dc.publisherWiley-Blackwellen_AU
dc.subjectTechnetium 99en_AU
dc.subjectRadioisotope generatorsen_AU
dc.subjectMolybdenum 98en_AU
dc.subjectGelsen_AU
dc.subjectTitaniumen_AU
dc.subjectZirconiumen_AU
dc.titleDevelopment of alternative technologies for a gel-type chromatographic Tc-99m generatoren_AU
dc.typeConference Abstracten_AU
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