Development of alternative technologies for a gel-type chromatographic Tc-99m generator
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Date
1994-04-01
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Wiley-Blackwell
Abstract
There is continuing concern worldwide about the need for multiple sources of the 99Mo generator, and the large investment required to introduce the use of 235U (n, f) 99Mo derived production at a mew facility. This is sufficient justification required for research on the development of technologies for a gel-type chromatographic 99mTc generator based on the 98Mo(n,r)99 Mo nuclear reaction. The synthesis of Titanium-Molybdate (abbrev. TiMo) generator packing gel pre-formed for 98Mo(n,r)99 Mo neutron activation of TiMo; and Zirconium-Molybdate (abbrev. ZrMo) gel columns containing (n,r) produced 99Mo for preparation of chromatographic 98mTc generators was studied. The chemistry of polymerisation, and amorphous or crystalline TiMo and ZrMo formating of the molybdate polyanion was investigated for the interpretation of the 99mTc-elution performance from the gel generators. Preparatory conditions of TiMo and ZrMo were found to be very critical. The complexity in the preparation of TiMo and ZrMo is attributed to the large capability of polymeric hydroxl complexes of Ti+4 and Zr+4 ions in the aqueous solution. The preparation of TiMo and ZrMo requires a process of high standardisation to give a product of consistent quality. X-ray diffraction patterns of the MoTi gel were similar between batches. Behaviours, such as target temperature, irradiation stability, and neutron self-shielding, of the TiMo gel under reactor irradiation conditions that effect the performance of the generator and the quality of the 99mTc pertechnetate elucate were measured. The specifications of TiMo and ZiMo gel columns of high 99mTc elution performance, and chromatographic 99mTc generator options yielding 99mTc fulfilling the requirements for nuclear medicine applications with several conventional kits will be illustratively described. The eluents used in the generator options are saline, redistilled water, or even organic solvent such as acetone, MEK. Fifty gel generators this type were tested in different hospitals in Vietnam, and gave satifactory results. The gel generator concept is particularly relevant to hospitals in developing countries that do not have access to fission produced 99Mo generators. Also a satisfactory gel-type generator based on (n,r)99 Mo Should be economical to produce. © 1994, Wiley-Blackwell
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Keywords
Technetium 99, Radioisotope generators, Molybdenum 98, Gels, Titanium, Zirconium
Citation
Le, V.S., Lambrecht, R. M. (1994). Development of alternative technologies for a gel-type chromatographic Tc-99 generator. Presentation to the 10th International Symposium on Radiopharmaceutical Chemistry, 25th-28th Oct 1993, Kyoto, Japan, In Journal of Labelled Compounds and Radiopharmaceuticals, 35(S1), 270-272