Alternative method for Cu-64 radioisotope production

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dc.contributor.authorLe, VSen_AU
dc.contributor.authorHowse, Jen_AU
dc.contributor.authorZaw, Men_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorWeiner, Ren_AU
dc.date.accessioned2010-07-29T00:15:12Zen_AU
dc.date.available2010-07-29T00:15:12Zen_AU
dc.date.issued2008-05-12en_AU
dc.date.statistics2009-07-01en_AU
dc.description.abstractThe method for 64Cu production based on a 64Ni target using an 18 MeV proton energy beam was developed. The studies on the optimisation of targetry for the 18 MeV proton bombardments were performed in terms of the cost-effective target utilisation and purity of the 64Cu product. The thickness-specific 64Cu yield (μCi/(μA×μm)) was introduced into the optimisation calculation with respect to cost-effective target utilisation. A maximum target utilisation efficacy factor (TUE) was found for the proton energy range of 2.5–13 MeV with corresponding target thickness of 36.2 μm. With the optimised target thickness and proton energy range, the 64Ni target thickness saving of 45.6% was achieved, while the overall 64Cu yield loss is only 23.9%, compared to the use of the whole effective proton energy range of 0–18 MeV with target thickness of 66.6 μm. This optimisation has the advantage of reducing the target amount to a reasonable level, and therefore the cost of the expensive 64Ni target material. The 64Ni target electroplated on the Au–Tl multi layer coated Cu-substrate was a new and competent design for an economic production of high quality 64Cu radioisotope using an 18 MeV proton energy cyclotron or a 30 MeV cyclotron with proton beam adjustable to 18 MeV. In this design, the Au coating layer plays a role of protection of “cold” Cu leakage from the Cu substrate and Tl serves to depress the proton beam energy (from 18 MeV to the energy optimised value 13 MeV). The ion exchange chromatographic technique with a gradient elution was applied to improve the 64Cu separation with respect to reducing the processing time and control of 64Cu product quality. © 2009, Elsevier Ltd.en_AU
dc.identifier.citationLe, V. S., Howse, J., Zaw, M., Pellegrini, P., Katsifis, A., Greguric, I., & Weiner. R. (2009). Alternative method for Cu-64 radioisotope production. Paper presented to the 6th International Conference on Isotopes (6ICI), 12th - 16th May 2008. Sheraton Grande Walkerhill Hotel: Seoul, South Korea. In Applied Radiation and Isotopes, 67(7-8), 1324-1331. doi:10.1016/j.apradiso.2009.02.069en_AU
dc.identifier.conferenceenddate16 May 2008en_AU
dc.identifier.conferencename6th International Conference on Isotopes (6ICI)en_AU
dc.identifier.conferenceplaceSeoul, Koreaen_AU
dc.identifier.conferencestartdate12 May 2008en_AU
dc.identifier.govdoc2044en_AU
dc.identifier.issn0969-8043en_AU
dc.identifier.issue7-8en_AU
dc.identifier.journaltitleApplied Radiation and Isotopesen_AU
dc.identifier.pagination1324-1331en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.apradiso.2009.02.069en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1944en_AU
dc.identifier.volume67en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectCopper 64en_AU
dc.subjectIsotope productionen_AU
dc.subjectIon exchange chromatographyen_AU
dc.subjectProton beamsen_AU
dc.subjectEnergy rangeen_AU
dc.subjectCyclotronsen_AU
dc.titleAlternative method for Cu-64 radioisotope productionen_AU
dc.typeConference Paperen_AU
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