Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials.

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dc.contributor.authorRamachandran, Sen_AU
dc.contributor.authorTaraban, MBen_AU
dc.contributor.authorTrewhella, Jen_AU
dc.contributor.authorGryczynski, Ien_AU
dc.contributor.authorGryczynski, Zen_AU
dc.contributor.authorYu, YBen_AU
dc.date.accessioned2010-07-02T05:15:31Zen_AU
dc.date.available2010-07-02T05:15:31Zen_AU
dc.date.issued2010-06-01en_AU
dc.date.statistics2010-06en_AU
dc.description.abstractMutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations, including dynamic rheometry, small-angle X-ray scattering (SAXS), and fluorescence spectroscopy, were used to investigate hydrogelation at the bulk, fiber, and molecular levels, respectively. It has been found that temperature has a significant effect on the structure and mechanical properties of peptide-based biomaterials. Oligopeptide fibers assembled at 25°C are formed faster and are two times thicker, and the resulting material is mechanically seven times stronger than that assembled at 5°C. © 2010, American Chemical Societyen_AU
dc.identifier.citationRamachandran, S., Taraban, M. B., Trewhella, J., Gryczynski, I., Gryczynski, Z., & Yu, Y. B. (2010). Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials. Biomacromolecules, 11(6), 1502-1506. doi:10.1021/bm100138men_AU
dc.identifier.govdoc1802en_AU
dc.identifier.issn1525-7797en_AU
dc.identifier.issue6en_AU
dc.identifier.journaltitleBiomacromoleculesen_AU
dc.identifier.pagination1502-1506en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/bm100138men_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/1721en_AU
dc.identifier.volume11en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectHydrogelsen_AU
dc.subjectPeptidesen_AU
dc.subjectTemperature rangeen_AU
dc.subjectMechanical propertiesen_AU
dc.subjectSmall angle scatteringen_AU
dc.subjectFluorescence spectroscopyen_AU
dc.titleEffect of temperature during assembly on the structure and mechanical properties of peptide-based materials.en_AU
dc.typeJournal Articleen_AU
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