Stabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV.

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dc.contributor.authorDaly, HLen_AU
dc.contributor.authorHall, MDen_AU
dc.contributor.authorFailes, TWen_AU
dc.contributor.authorZhang, Men_AU
dc.contributor.authorForan, GJen_AU
dc.contributor.authorHambley, TWen_AU
dc.date.accessioned2011-03-30T05:06:19Zen_AU
dc.date.available2011-03-30T05:06:19Zen_AU
dc.date.issued2011-03-11en_AU
dc.date.statistics2011-03-11en_AU
dc.description.abstractPtIV analogues of the active end groups {PtClN3} of multinuclear Pt anticancer drugs have been investigated. The crystal structure of trans,mer-[PtCl(OH)2(dien)]Cl shows that the bond lengths are similar to those in the dihydroxidoplatinum(iv) analogue of cisplatin. The axial ligands are shown to be the predominant influence on reduction potentials with the dihydroxido complex trans,mer-[PtCl(OH)2(NH3)3]Cl being the most resistant to reduction. X-ray absorption near-edge spectroscopy is shown to be suitable for monitoring the oxidation state of these complexes and reveals that trans,mer-[PtCl(OH)2(NH3)3]+ survives for more than 2 h in cancer cells. © 2011, CSIRO Publishingen_AU
dc.identifier.citationDaly, H. L., Hall, M. D., Failes, T. W., Zhang, M., Foran, G. J., & Hambley, T. W. (2011). Stabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV. Australian Journal of Chemistry, 64(3), 273-278. doi:10.1071/CH11041en_AU
dc.identifier.govdoc3330en_AU
dc.identifier.issn0004-9425en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleAustralian Journal of Chemistryen_AU
dc.identifier.pagination273-278en_AU
dc.identifier.urihttp://dx.doi.org/10.1071/CH11041en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/3163en_AU
dc.identifier.volume64en_AU
dc.language.isoenen_AU
dc.publisherCSIRO Publishingen_AU
dc.subjectOxidationen_AU
dc.subjectDrugsen_AU
dc.subjectCrystal structureen_AU
dc.subjectAbsorption spectroscopyen_AU
dc.subjectNeoplasmsen_AU
dc.subjectComplexesen_AU
dc.titleStabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV.en_AU
dc.typeJournal Articleen_AU
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