Stabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV.
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Date
2011-03-11
Journal Title
Journal ISSN
Volume Title
Publisher
CSIRO Publishing
Abstract
PtIV analogues of the active end groups {PtClN3} of multinuclear Pt anticancer drugs have been investigated. The crystal structure of trans,mer-[PtCl(OH)2(dien)]Cl shows that the bond lengths are similar to those in the dihydroxidoplatinum(iv) analogue of cisplatin. The axial ligands are shown to be the predominant influence on reduction potentials with the dihydroxido complex trans,mer-[PtCl(OH)2(NH3)3]Cl being the most resistant to reduction. X-ray absorption near-edge spectroscopy is shown to be suitable for monitoring the oxidation state of these complexes and reveals that trans,mer-[PtCl(OH)2(NH3)3]+ survives for more than 2 h in cancer cells. © 2011, CSIRO Publishing
Description
Keywords
Oxidation, Drugs, Crystal structure, Absorption spectroscopy, Neoplasms, Complexes
Citation
Daly, H. L., Hall, M. D., Failes, T. W., Zhang, M., Foran, G. J., & Hambley, T. W. (2011). Stabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV. Australian Journal of Chemistry, 64(3), 273-278. doi:10.1071/CH11041